Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipoprotein[a]), with some ...

This review focuses on the non-statin strategies for the treatment of hyperlipidemias in humans. Even if statins remain the major hypolipidemic drugs at present, ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19isanemerging,rapidlyevolvingsituation.GetthelatestpublichealthinformationfromCDC:https://www.coronavirus.govGetthelatestresearchinformationfromNIH:https://www.nih.gov/coronavirusFindNCBISARS-CoV-2literature,sequence,andclinicalcontent:https://www.ncbi.nlm.nih.gov/sars-cov-2/ AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:To:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksElsevierScienceFull-textlinksActionsCi

Combination Drugs. These combination drugs lower lipids: Lovastatin and niacin ( nicotinic acid). Atorvastatin and amlodipine. Simvastatin and ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjE3MjE3Mi1vdmVydmlldw==processing....Drugs&Diseases>ProtocolsLipid-LoweringAgents Updated:May18,2020Author:AbimbolaFarinde,PharmD,PhD;more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsLipid-LoweringAgentsSectionsLipid-LoweringAgentsLipid-LoweringAgentsQuestions&AnswersShowAllReferencesLipid-LoweringAgentsHMG-CoAreductaseinhibitors(statins)Theseagentsinhibittherate-limitingstepincholesterolbiosynthesisbycompetitivelyinhibitingHMG-CoAreductase.[1]Notethefollowing:Low-densitylipoprotein(LDL)reductionof25%-60%ExamplesincludeAtorvastatin,fluvastatin,lovastatin,pitavastatin,pravastatin,rosuvastatin,simvastatinContraindicationsincludehypersensitivity,activeliverdisease,pregnancy,lactation,coadministrationwithstrongCYP3A4inhibitors(selectedstatins)VitaminB3VitaminB3inhibitsvery-low-densitylipoprotein(VLDL)synthesis.Notethefollowing:LDLreductionof10%High-densitylipoprotein(HDL)increaseof20%ExampleincludesNiacin(nicotinicacid)Contraindicationsincludehypersensitivity,liverdisease,activepepticulcer,severehypotension,arterialbleedingFibratesFibratesenhancelipoproteinlipase,resultinginincreasedVLDLcatabolism,fattyacidoxidation,andtriglycerideselimination.Theydecreasehepaticextractionoffreefattyacids.Notethefollowing:LDLreductionof15%Triglyceridereductionof35%Examplesinc

A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle ...HypolipidemicAgentsAllcategoriesNameHypolipidemicAgentsAccessionNumberDBCAT000274DescriptionSubstancesthatlowerthelevelsofcertainLIPIDSintheBLOOD.TheyareusedtotreatHYPERLIPIDEMIAS.DrugsDrugDrugDescriptionCholineAnutrientfoundinawidevarietyofvitaminsincludingpre-natalformulations.IcosapentApolyunsaturatedfattyacid,usuallyfoundinfishoils,thatisusedinmanysupplements.PravastatinAnHMG-CoAreductaseinhibitorusedtolowerlipidlevelsandtoreducetheriskofcardiovascularevents,includingmyocardialinfarctionandstroke.LovastatinAnHMG-CoAreductaseinhibitorusedtolowerLDLcholesterolandreducetheriskofcardiovasculardiseaseandassociatedconditions,includingmyocardialinfarctionandstroke.ColestipolAbileacidsequestrantusedasanadjuncttodietandexercisetoreduceLDL-Ccholesterollevelsinpatientswithprimaryhypercholesterolemia.CerivastatinAstatin(orHMGCoAreductaseinhibitor)usedwithdietarychangestodecreaselipidlevelsandreducetheriskofcardiovascularevents.EthionamideAsecondlineantitubercularagentusedtotreattuberculosiswhenothertreatmentshavefailed.NiacinABvitaminusedtotreathypertriglyceridemiaandpellagra.ClofibrateAfibricacidderivativeusedtotreathypertriglyceridemiaandhighcholesterol.SimvastatinAnHMG-CoAreductaseinhibitorusedtolowerlipidlevelsandreducetheriskofcardiovasculareventsincludingmyocardialinfarctionandstroke.ColesevelamAbileacidsequestrantusedtolowerLDL-Cinadultswithhyperlipidemiaandpediatricpatientswithheterozygousfamilialhypercholesterolemia,andtoimproveglycemiccontrolintype2diabetes.IsoniazidAnantibioticusedtotreatmycobacterialinfections;mostcommonlyuseincombinationwithotherantimycobacterialagentsforthetreatmentofactiveorlatenttuberculosis.EzetimibeAcholesterolabsorptioninhibitorusedtolowertotalcholesterol,LDL-C,Apo-B,andnon-HDL-Cinprimaryhyperlipidemiaandfamilialcholesterolemia.CeruleninForuseasabiochemicaltool,Ceruleninisshowntocaus

Three classes of hypolipidaemic drugs are used currently for the prevention of cardiovascular diseases. Resins, by binding bile acids, prevent the intestinal ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19isanemerging,rapidlyevolvingsituation.GetthelatestpublichealthinformationfromCDC:https://www.coronavirus.govGetthelatestresearchinformationfromNIH:https://www.nih.gov/coronavirusFindNCBISARS-CoV-2literature,sequence,andclinicalcontent:https://www.ncbi.nlm.nih.gov/sars-cov-2/ AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:To:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatA

Hypolipidemic drug, also called lipid-lowering drug, any agent the reduces the level of lipids and lipoproteins (lipid-protein complexes) in the blood. Statins are hypolipidemic drugs that block the enzyme HMG-CoA (5-hydroxy-3-methylglutaryl-coenzyme A) reductase, which is required for the synthesis of cholesterol.HypolipidemicdrugArticleAdditionalInfoHomeHealth&MedicineMedicineHypolipidemicdrugPrintCiteverifiedCiteWhileeveryefforthasbeenmadetofollowcitationstylerules,theremaybesomediscrepancies.Pleaserefertotheappropriatestylemanualorothersourcesifyouhaveanyquestions.SelectCitationStyleMLAAPAChicagoManualofStyleCopyCitationShareShareSharetosocialmediaFacebookTwitterURLhttps://www.britannica.com/science/hypolipidemic-drugMoreGiveFeedbackExternalWebsitesFeedbackCorrections?Updates?Omissions?Letusknowifyouhavesuggestionstoimprovethisarticle(requireslogin).FeedbackTypeSelectatype(Required)FactualCorrectionSpelling/GrammarCorrectionLinkCorrectionAdditionalInformationOtherYourFeedbackSubmitFeedbackThankyouforyourfeedbackOureditorswillreviewwhatyou’vesubmittedanddeterminewhethertorevisethearticle.JoinBritannica'sPublishingPartnerProgramandourcommunityofexpertstogainaglobalaudienceforyourwork!ExternalWebsitesNationalCenterforBiotechnologyInformation-PubMedCentral-Lipid-loweringdrugsWRITTENBYJanetL.StringerAssociateProfessorofPharmacology,BaylorCollegeofMedicine,Houston,TX.SeeArticleHistoryHypolipidemicdrug,alsocalledlipid-loweringdrug,anyagentthereducestheleveloflipidsandlipoproteins(lipid-proteincomplexes)intheblood.Lipoproteinsbindcholesterolandcanaccumulateinbloodvessels.Highlevelsofspecificlipoproteins,namely,low-densitylipoprotein(LDL)andverylow-densitylipoprotein(VLDL),havebeenassociatedwithanelevatedriskofcertainformsofcardiovasculardisease,includingcoronaryarterydisease,heartattack,andstroke.StatinsarehypolipidemicdrugsthatblocktheenzymeHMG-CoA(5-hydroxy-3-methylglutaryl-coenzymeA)reductase,whichisrequiredforthesynthesisofcholesterol.Examplesofstatinsincludesimvast

Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high ...Lipid-loweringagentFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchHypolipidemicagents,cholesterol-loweringdrugsorantihyperlipidemicagents,areadiversegroupofpharmaceuticalsthatareusedinthetreatmentofhighlevelsoffats(lipids),suchascholesterol,intheblood(hyperlipidemia).Theyarecalledlipid-loweringdrugs.Thesearedrugswhichlowertheleveloflipidsandlipoproteinsinblood.Contents1Classes1.1Established2Research3References4SeealsoClasses[edit]Theseveralclassesofhypolipidemicdrugsmaydifferinboththeirimpactonthecholesterolprofileandadverseeffects.Forexample,somemaylowerthe"badcholesterol"lowdensitylipoprotein(LDL)moresothanothers,whileothersmaypreferentiallyincreasehighdensitylipoprotein(HDL),"thegoodcholesterol".Clinically,thechoiceofanagentdependsonthepatient'scholesterolprofile,cardiovascularrisk,andtheliverandkidneyfunctionsofthepatient,evaluatedagainstthebalancingofrisksandbenefitsofthemedications.IntheUnitedStates,thisisguidedbytheevidence-basedguidelinemostrecentlyupdatedin2018bytheAmericanCollegeofCardiology&AmericanHeartAssociation.[1]Established[edit]Statins(HMG-CoAreductaseinhibitors)areparticularlywellsuitedforloweringLDL,thecholesterolwiththestrongestlinkstovasculardiseases.Instudiesusingstandarddoses,statinshavebeenfoundtolowerLDL-Cby18%to55%,dependingonthespecificstatinbeingused.Ariskexistsofmuscledamage(myopathyandrhabdomyolysis)withstatins.Hypercholesterolemiaisnotariskfactorformortalityinpersonsolderthan70yearsandrisksfromstatindrugsaremoreincreasedafterage85.[2]Fibratesareindicatedforhypertriglyceridemia.Fibratestypicallylowertriglyceridesby20%to50%.LevelofthegoodcholesterolHDLisalsoincreased.FibratesmaydecreaseLDL,thoughgenerallytoalesserdegreethanstatins.Similartostatins,theriskofmuscledamageexists.Niacin,likefibrates,isalsowellsuitedforloweringtriglyceridesby20–50%.ItmayalsolowerLDLby5–25

降血脂用藥Hypolipidemic agents (= antihyperlipidemic agents = lipid-lowering drugs) Statin類(HMG CoA.關閉廣告~Teachingcenter的醫學筆記~跳到主文如有錯誤歡迎各方專家指正謝謝部落格全站分類：醫療保健相簿部落格留言名片圖片太大，可以右鍵或長按後在新分頁開啟***更多討論***痞客邦--醫學邦***點我前往***~~~MAX台灣唯一信託加密貨幣交易所~~~有幫助的文章，可以給個推或讚，讓我知道哪些是對大家有益的Mar27Wed201920:13降血脂用藥Hypolipidemicagents(=antihyperlipidemicagents=lipid-loweringdrugs)降血脂用藥Hypolipidemicagents(=antihyperlipidemicagents=lipid-loweringdrugs) Statin類(HMGCoAreductaseinhibitors)對降血脂的效果 AtorvastatinFluvastatinLovastatinPravastatinRosuvastatinSimvastatinLDL↓50%24%34%34%50%41%TG↓29%10%16%24%18%18%HDL↑6%8%9%12%8%12%半衰期14小時1~2小時2小時1~2小時19小時1~2小時進CNS不會不會可以不會不會可以腎排出2%5%10%20%10%13%LDL=low-densitylipoprotein、HDL=high-densitylipoproteinTG=triglycerols 各類降血脂藥的效果藥物種類LDLHDLTriglycerolsHMGCoAreductaseinhibitors(statins)↓↓↓↓↑↑↓↓Fibrates↓↑↑↑↓↓↓↓Niacin↓↓↑↑↑↑↓↓↓Bileacidsequestrants↓↓↓↑MinimalCholesterolabsorptioninhibitor↓↑↓LDL=low-densitylipoprotein、HDL=high-densitylipoprotein 治療藥物建議Single-drugtherapywithmarineomega-3dietarysupplementshouldbeevaluatedbeforedrugcombinationsareused.Primarychylomicronemia(familiallipoproteinlipaseorcofactordeficiency:others)-Manifestations:chylomicrons,VLDLincreased-Diet+Singledrug:dietarymanagement(omega-3fattyacids,niacin,orfibrate)-Drugcombination:niacin+fibrate Familialhypertriglyceridemia(severe)-Manifestations:VLDL,chylomicronsincreased-Diet+Singledrug:omega-3fattyacids,niacinorfibrate-Drugcombination:niacin+fibrate Familialhypertriglyceridemia(moderate)-Manifestations:VLDLincreased,chylomicronsmaybeincreased-Diet+Singledrug:omega-3fattyacids,niacinorfibrate-Drugcombination:niacin+fibrate Familialcombinedhyperlipoproteinemia(VLDL)-Manifestations:VLDLpredominantlyincreased-Diet+Singledrug:omega-3fattyacids,niacin,fibrate,orreductaseinhibitor-Drugcombination:twoorthreeoftheindividualdrugs Familialcombinedhyperlipoproteinemia(LDL)-Manifestations:LDLpredominantlyincreased-Diet+Singledrug:niacin,reductaseinhibitor,orezetimibe-Drugcombination:twoorthreeoftheindividualdrugs Familialco