Combination Drugs. These combination drugs lower lipids: Lovastatin and niacin ( nicotinic acid). Atorvastatin and amlodipine. Simvastatin and ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjE3MjE3Mi1vdmVydmlldw==processing....Drugs&Diseases>ProtocolsLipid-LoweringAgents Updated:May18,2020Author:AbimbolaFarinde,PharmD,PhD;more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsLipid-LoweringAgentsSectionsLipid-LoweringAgentsLipid-LoweringAgentsQuestions&AnswersShowAllReferencesLipid-LoweringAgentsHMG-CoAreductaseinhibitors(statins)Theseagentsinhibittherate-limitingstepincholesterolbiosynthesisbycompetitivelyinhibitingHMG-CoAreductase.[1]Notethefollowing:Low-densitylipoprotein(LDL)reductionof25%-60%ExamplesincludeAtorvastatin,fluvastatin,lovastatin,pitavastatin,pravastatin,rosuvastatin,simvastatinContraindicationsincludehypersensitivity,activeliverdisease,pregnancy,lactation,coadministrationwithstrongCYP3A4inhibitors(selectedstatins)VitaminB3VitaminB3inhibitsvery-low-densitylipoprotein(VLDL)synthesis.Notethefollowing:LDLreductionof10%High-densitylipoprotein(HDL)increaseof20%ExampleincludesNiacin(nicotinicacid)Contraindicationsincludehypersensitivity,liverdisease,activepepticulcer,severehypotension,arterialbleedingFibratesFibratesenhancelipoproteinlipase,resultinginincreasedVLDLcatabolism,fattyacidoxidation,andtriglycerideselimination.Theydecreasehepaticextractionoffreefattyacids.Notethefollowing:LDLreductionof15%Triglyceridereductionof35%Examplesinc