降血脂用藥Hypolipidemic agents (= antihyperlipidemic agents = lipid-lowering drugs) Statin類(HMG CoA.關閉廣告~Teachingcenter的醫學筆記~跳到主文如有錯誤歡迎各方專家指正謝謝部落格全站分類：醫療保健相簿部落格留言名片圖片太大，可以右鍵或長按後在新分頁開啟***更多討論***痞客邦--醫學邦***點我前往***~~~MAX台灣唯一信託加密貨幣交易所~~~有幫助的文章，可以給個推或讚，讓我知道哪些是對大家有益的Mar27Wed201920:13降血脂用藥Hypolipidemicagents(=antihyperlipidemicagents=lipid-loweringdrugs)降血脂用藥Hypolipidemicagents(=antihyperlipidemicagents=lipid-loweringdrugs) Statin類(HMGCoAreductaseinhibitors)對降血脂的效果 AtorvastatinFluvastatinLovastatinPravastatinRosuvastatinSimvastatinLDL↓50%24%34%34%50%41%TG↓29%10%16%24%18%18%HDL↑6%8%9%12%8%12%半衰期14小時1~2小時2小時1~2小時19小時1~2小時進CNS不會不會可以不會不會可以腎排出2%5%10%20%10%13%LDL=low-densitylipoprotein、HDL=high-densitylipoproteinTG=triglycerols 各類降血脂藥的效果藥物種類LDLHDLTriglycerolsHMGCoAreductaseinhibitors(statins)↓↓↓↓↑↑↓↓Fibrates↓↑↑↑↓↓↓↓Niacin↓↓↑↑↑↑↓↓↓Bileacidsequestrants↓↓↓↑MinimalCholesterolabsorptioninhibitor↓↑↓LDL=low-densitylipoprotein、HDL=high-densitylipoprotein 治療藥物建議Single-drugtherapywithmarineomega-3dietarysupplementshouldbeevaluatedbeforedrugcombinationsareused.Primarychylomicronemia(familiallipoproteinlipaseorcofactordeficiency:others)-Manifestations:chylomicrons,VLDLincreased-Diet+Singledrug:dietarymanagement(omega-3fattyacids,niacin,orfibrate)-Drugcombination:niacin+fibrate Familialhypertriglyceridemia(severe)-Manifestations:VLDL,chylomicronsincreased-Diet+Singledrug:omega-3fattyacids,niacinorfibrate-Drugcombination:niacin+fibrate Familialhypertriglyceridemia(moderate)-Manifestations:VLDLincreased,chylomicronsmaybeincreased-Diet+Singledrug:omega-3fattyacids,niacinorfibrate-Drugcombination:niacin+fibrate Familialcombinedhyperlipoproteinemia(VLDL)-Manifestations:VLDLpredominantlyincreased-Diet+Singledrug:omega-3fattyacids,niacin,fibrate,orreductaseinhibitor-Drugcombination:twoorthreeoftheindividualdrugs Familialcombinedhyperlipoproteinemia(LDL)-Manifestations:LDLpredominantlyincreased-Diet+Singledrug:niacin,reductaseinhibitor,orezetimibe-Drugcombination:twoorthreeoftheindividualdrugs Familialco