Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high ...Lipid-loweringagentFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchHypolipidemicagents,cholesterol-loweringdrugsorantihyperlipidemicagents,areadiversegroupofpharmaceuticalsthatareusedinthetreatmentofhighlevelsoffats(lipids),suchascholesterol,intheblood(hyperlipidemia).Theyarecalledlipid-loweringdrugs.Thesearedrugswhichlowertheleveloflipidsandlipoproteinsinblood.Contents1Classes1.1Established2Research3References4SeealsoClasses[edit]Theseveralclassesofhypolipidemicdrugsmaydifferinboththeirimpactonthecholesterolprofileandadverseeffects.Forexample,somemaylowerthe"badcholesterol"lowdensitylipoprotein(LDL)moresothanothers,whileothersmaypreferentiallyincreasehighdensitylipoprotein(HDL),"thegoodcholesterol".Clinically,thechoiceofanagentdependsonthepatient'scholesterolprofile,cardiovascularrisk,andtheliverandkidneyfunctionsofthepatient,evaluatedagainstthebalancingofrisksandbenefitsofthemedications.IntheUnitedStates,thisisguidedbytheevidence-basedguidelinemostrecentlyupdatedin2018bytheAmericanCollegeofCardiology&AmericanHeartAssociation.[1]Established[edit]Statins(HMG-CoAreductaseinhibitors)areparticularlywellsuitedforloweringLDL,thecholesterolwiththestrongestlinkstovasculardiseases.Instudiesusingstandarddoses,statinshavebeenfoundtolowerLDL-Cby18%to55%,dependingonthespecificstatinbeingused.Ariskexistsofmuscledamage(myopathyandrhabdomyolysis)withstatins.Hypercholesterolemiaisnotariskfactorformortalityinpersonsolderthan70yearsandrisksfromstatindrugsaremoreincreasedafterage85.[2]Fibratesareindicatedforhypertriglyceridemia.Fibratestypicallylowertriglyceridesby20%to50%.LevelofthegoodcholesterolHDLisalsoincreased.FibratesmaydecreaseLDL,thoughgenerallytoalesserdegreethanstatins.Similartostatins,theriskofmuscledamageexists.Niacin,likefibrates,isalsowellsuitedforloweringtriglyceridesby20–50%.ItmayalsolowerLDLby5–25