Here, we report a case of NK/T-cell lymphoma involving the sinonasal region ... 1​Division of Pathology, Sijhih Cathay General Hospital, New Taipei City, Taiwan ... cells show readily discernible nuclear atypia with an irregular nuclear outline ...CaseReportsinPathology+JournalMenuPDFJournaloverviewForauthorsForreviewersForeditorsTableofContentsSubmitCaseReportsinPathology/2018/ArticleArticleSectionsOnthispageAbstractIntroductionCaseReportDiscussionAbbreviationsDisclosureConflictsofInterestAuthors’ContributionsReferencesCopyrightCaseReport|OpenAccessVolume2018|ArticleID6264810|https://doi.org/10.1155/2018/6264810Chih-YiLiu,Hui-ChihTsai,"ComparisonofDiagnosticCytomorphologyofNaturalKiller/T-CellLymphoma(NasalType)inConventionalSmears,Liquid-BasedPreparations,andHistopathology",CaseReportsinPathology,vol.2018,ArticleID6264810,7pages,2018.https://doi.org/10.1155/2018/6264810ShowcitationComparisonofDiagnosticCytomorphologyofNaturalKiller/T-CellLymphoma(NasalType)inConventionalSmears,Liquid-BasedPreparations,andHistopathologyChih-YiLiu1,2andHui-ChihTsai11DivisionofPathology,SijhihCathayGeneralHospital,NewTaipeiCity,Taiwan2CollegeofMedicine,FuJenCatholicUniversity,NewTaipeiCity,TaiwanShowmoreAcademicEditor:MariaM.PickenReceived26Dec2017Accepted08Apr2018Published14May2018Naturalkiller(NK)/T-celllymphomaisformallyreferredtoasextranodalNK/T-celllymphoma,nasaltype(ENKTCL),inthe2008and2016WorldHealthOrganization(WHO)classifications.NK/T-celllymphoma,nasaltype,isararebutclinicallyimportantlymphoidneoplasm.ItisthepredominanttypeofextranodallymphomaassociatedwiththeEpstein–Barrvirus(EBV).NK/T-celllymphomaismarkedbyawidecytomorphologicalspectrum.ThecytologicalfindingsmaybesosubtlethatNK/T-celllymphomacouldpossiblybeeasilyoverlooked.Here,wereportacaseofNK/T-celllymphomainvolvingthesinonasalregionwithlymphnodeinvolvement.Fineneedleaspirationofthenecklymphnodeandpunchbiopsyofthenasalmucosawereperformed.ThediagnosisofNK/T-celllymphomawasconfirmedbasedonpathologicalandimmunohistochemic

T/NK cell neoplasms are clonal tumors of mature and immature T cells or natural killer cells at various stages of differentiation (WHO 2008) ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsClickheretoregisterforourworldwidepathologistdirectory.Currentregistrationleaders:Harvard,Icahn,MCWJobsFellowshipsConferences/WebinarsDirectoryBooksCMECasesAdvertiseGrantsCCNLibrariesSampleLibraryCOVID-19LibraryPandemicreliefmusicawardMedicalNewsHome>Lymphoma&relateddisorders>T/NKcelldisorders-generalLymphoma&relateddisordersMatureT/NKcelldisordersT/NKcelldisorders-generalAuthor: DragosC.Luca,M.D.TopicCompleted:1January2012Minorchanges:30December2020Copyright:2001-2021,PathologyOutlines.com,Inc.PubMedSearch:T/NKcelldisordersPageviewsin2020:1,403Pageviewsin2021todate:1,010TableofContentsDefinition/general|Epidemiology|Sites|Pathophysiology|Etiology|Microscopic(histologic)description|Immunohistochemistry|Molecular/cytogeneticsdescriptionCitethispage:LucaDC.T/NKcelldisorders-general.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/lymphomanonBTcellgeneral.html.AccessedJuly6th,2021.Definition/generalT/NKcellneoplasmsareclonaltumorsofmatureandimmatureTcellsornaturalkillercellsatvariousstagesofdifferentiation(WHO2008)TandNKneoplasmsareconsideredtogetherbecausetheyarecloselyrelatedandshareimmunophenotypicandfunctionalpropertiesEpidemiologyPrecursorTlymphoidneoplasms(T-ALL/LBL):primarilydiseasesofchildren/youngadults,10-15%ofacutelymphoblasticleukemia(ALL),85-90%oflymphoblasticlymphoma(LBL),malepredominance(PediatrBloodCancer2008;51:489)MatureT/NKcellneoplasms:relativelyuncommon;15%ofnon-HodgkinlymphomasinU.S./WesternEurope;areusuallyaggressivewithmediansurvivalof10-30monthsLargeinternationalstudy(Blood1997;89:3909):12%ofallNHLareT/NKcell(peripheralTcelllymphomaNOS-25.9%,angioimmunoblasticTcelllymphoma-18.5%)Significantgeographicandracialincidencevariation:generallymorecommoninAsiaorAsianpopulations;adultTcellleukemia/lymphomainendemicHTLV-Iar

The skin is secondarily involved but a disease based primarily in the skin may also occur. Histology of extranodal NK/T cell lymphoma, nasal type. In extranodal​ ...DermNetprovidesGoogleTranslate,afreemachinetranslationservice.Notethatthismaynotprovideanexacttranslationinalllanguageslogo-newThispagewasprintedon7/7/2021HomeTopicsA–ZImagesBrowseDermDiagGlossaryQuizzesAboutContactJobsDonatebreadcrumbsHome»TopicsA–Z»ExtranodalNK/Tcelllymphoma,nasaltype,pathologyExtranodalNK/Tcelllymphoma,nasaltype,pathologyAuthor:AssocProfPatrickEmanuel,Dermatopathologist,Auckland,NewZealand,2013.ExtranodalNK/Tcelllymphoma,nasaltype,pathology—codesandconceptsopenSynonyms:AngiocentricTcelllymphomapathology,T/NKcelllymphomapathologyCategories:Pathology,Tumour,ViralinfectionSubcategories:RoleofEBVinextranodalNK/Tcelllymphoma,nasaltype,EpsteinBarrvirus,EBV-associatedlymphoproliferativedisorderICD-10:C86.0ICD-11:2A90.6SNOMEDCT:414166008,40168006IntroductionExtranodalNK/Tcelllymphoma,nasaltype,isanEpstein-Barrvirus(EBV)-drivendiseasewhichtypicallyprimarilyinvolvestheupperrespiratorytract(seeEpstein–Barrvirus-associatedlymphoproliferativedisorders).Theskinissecondarilyinvolvedbutadiseasebasedprimarilyintheskinmayalsooccur.HistologyofextranodalNK/Tcelllymphoma,nasaltypeInextranodalNK/Tcelllymphoma,nasaltype,thereisadensedermalinfiltrate(figure1)whichoftenextendsintothesubcutis.Exocytosisofatypicallymphocytesintotheepidermismaybeseenandmaycloselyresemblemycosisfungoides(figure2).Theinfiltrateinthedermisisusuallypolymorphousandmayincludenumeroushistiocytesandeosinophils.Theatypicalcellsaresmalltomediumsizedwithsomelargerforms(figures3,4).Commonly,theinfiltrateinfiltratesthewallsofvessels(figures3,4)causingvascularnucleardebris(seenfocallyinfigure4).Necrosisisanothercommonfinding.ExtranodalNK/Tcelllymphoma,nasaltypepathologyFigure1Figure2Figure3Figure4SpecialstudiesforextranodalNK/Tcelllymphoma,nasaltypeSpecialstainsareessentialformakingthediagnosis.In-situhybridizationwithEBVshowstheatypicalcells

Hepatosplenic T-cell lymphoma is a rare, aggressive T-cell lymphoma, characterized by ... on Diagnostic Differentiation From Other T-Cell/Natural Killer-​Cell Neoplasms ... 1 From the Department of Pathology, Duke University Medical Center, ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:26317456-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksSilverchairInformationSystemsFulltextlinksActionsCiteFavoritesDisplayoptionsD

Surgical Pathology Criteria ... Extranodal NK/T Cell Lymphoma, Nasal Type ... Polymorphic extranodal lymphoma, expressing NK or rarely cytotoxic T cell ...SurgicalPathologyCriteriahttp://surgpathcriteria.stanford.edu/usebrowserbackbuttontoreturnExtranodalNK/TCellLymphoma,NasalTypeDefinitionPolymorphicextranodallymphoma,expressingNKorrarelycytotoxicTcellphenotypeAlternate/HistoricalNamesPolymorphicreticulosisLethalmidlinegranulomaAngiocentricTcelllymphomaDiagnosticCriteriaPrimarilyextranodalMostcommonsiteisnoseNodesmaybeinvolvedsecondarilyNecrosisnearlyalwayspresentVasculardestructionmaybeseenUlcerationcommonPseudoepitheliomatoushyperplasiamaybeseenWiderangeofappearancefromsmalltolargecellFrequentlymixedInflammatorycellsmaybeprominentCytoplasmmaybeclearwithazurophilicgranulesonGiemsastainedcytologicpreparationsCD56positiveRarecasesmaylackCD56,butmustthenbeEBV+,CD3+andcytotoxicprotein+EBVpositiveMaybelackinginsomeextranasal,NorthAmericanorWesternEuropeancasesNotethattheterm"nasaltype"originallyappliedonlytolymphomasofthistypethatoccurredinsitesotherthanthenasalcavity;itnowincludesnasalandextra-nasallocationsDitaGratzingerMDPhDYasodhaNatkunamMDPhDRobertVRouseMDDepartmentofPathologyStanfordUniversitySchoolofMedicineStanfordCA94305-5342Initialposting:September1,2007SupplementalstudiesImmunohistologyandFlowNKtypeCD56100%EBVLMPPositive,lesssensitivethaninsituhybridizationCD3Cytoplasmicpositive,membranenegativeCytotoxicgranuleproteins:granzymeB,TIA1,perforinGenerallypositiveCD43,CD45ROGenerallypositiveCD20,CD79aRarepositivecasesreportedCD30OccasionallypositiveCD4,CD5,CD8NegativeTcelltypeCD56NegativeCD3PositiveCD5,CD8MaybepositiveCytotoxicgranuleproteins:granzymeB,TIA1,perforinRequiredfordiagnosisEBVRequiredfordiagnosisCD56isnotspecific,itmaybeseeninotherlymphomasandnon-lymphoidneoplasmsGeneticanalysisEBVEBERpositivebyinsituhybridization25-95%DependsongeographiclocationInendemicareas95%CaseswithNKphenotypewillhavegermlineTcellreceptorgeneconfigurationDifferentialDiagnosisNon

Extranodal NK/T-cell lymphoma, nasal type, is an EBV-positive, aggressive lymphoma characterized by prominent necrosis, vascular damage, ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListAcadPatholv.6;Jan-Dec2019PMC6902387AcadPathol.2019Jan-Dec;6:2374289519893083.Publishedonline2019Dec9.doi: 10.1177/2374289519893083PMCID:PMC6902387PMID:31840047EducationalCase:ExtranodalNK/T-CellLymphoma,NasalTypeYueJia,MD,PhD,1JoshuaByers,MD,1HolliMason,MD,1andXinQing,MD,PhD1YueJia1DepartmentofPathology,Harbor-UCLAMedicalCenter,Torrance,CA,USAFindarticlesbyYueJiaJoshuaByers1DepartmentofPathology,Harbor-UCLAMedicalCenter,Torrance,CA,USAFindarticlesbyJoshuaByersHolliMason1DepartmentofPathology,Harbor-UCLAMedicalCenter,Torrance,CA,USAFindarticlesbyHolliMasonXinQing1DepartmentofPathology,Harbor-UCLAMedicalCenter,Torrance,CA,USAFindarticlesbyXinQingAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimer1DepartmentofPathology,Harbor-UCLAMedicalCenter,Torrance,CA,USAXinQing,DepartmentofPathology,Harbor-UCLAMedicalCenter,1000WestCarsonStreet,Torrance,CA90509,USA.Email:vog.ytnuocal.shd@gniqxReceived2019May30;Revised2019Oct24;Accepted2019Nov2.Copyright©TheAuthor(s)2019ThisarticleisdistributedunderthetermsoftheCreativeCommonsAttribution-NonCommercial-NoDerivs4.0License(http://www.creativecommons.org/licenses/by-nc-nd/4.0/)whichpermitsnon-commercialuse,reproductionanddistributionoftheworkaspublishedwithoutadaptationoralteration,withoutfurtherpermissionprovidedtheoriginalworkisattributedasspecifiedontheSAGEandOpenAccesspages(https://us.sagepub.com/en-us/nam/open-access-at-sage).ThefollowingfictionalcaseisintendedasalearningtoolwithinthePathologyCompetenciesforMedicalEducation(PCME),asetofnationalstandardsforteachingpathology.Thesearedividedintothreebasiccompetencies:DiseaseMechanismsandProcesses,OrganSystemPathology,andDiagnosticMedicineandTherapeuticPathology.Foradditionalinform