T/NK cell neoplasms are clonal tumors of mature and immature T cells or natural killer cells at various stages of differentiation (WHO 2008) ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsClickheretoregisterforourworldwidepathologistdirectory.Currentregistrationleaders:Harvard,Icahn,MCWJobsFellowshipsConferences/WebinarsDirectoryBooksCMECasesAdvertiseGrantsCCNLibrariesSampleLibraryCOVID-19LibraryPandemicreliefmusicawardMedicalNewsHome>Lymphoma&relateddisorders>T/NKcelldisorders-generalLymphoma&relateddisordersMatureT/NKcelldisordersT/NKcelldisorders-generalAuthor: DragosC.Luca,M.D.TopicCompleted:1January2012Minorchanges:30December2020Copyright:2001-2021,PathologyOutlines.com,Inc.PubMedSearch:T/NKcelldisordersPageviewsin2020:1,403Pageviewsin2021todate:1,010TableofContentsDefinition/general|Epidemiology|Sites|Pathophysiology|Etiology|Microscopic(histologic)description|Immunohistochemistry|Molecular/cytogeneticsdescriptionCitethispage:LucaDC.T/NKcelldisorders-general.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/lymphomanonBTcellgeneral.html.AccessedJuly6th,2021.Definition/generalT/NKcellneoplasmsareclonaltumorsofmatureandimmatureTcellsornaturalkillercellsatvariousstagesofdifferentiation(WHO2008)TandNKneoplasmsareconsideredtogetherbecausetheyarecloselyrelatedandshareimmunophenotypicandfunctionalpropertiesEpidemiologyPrecursorTlymphoidneoplasms(T-ALL/LBL):primarilydiseasesofchildren/youngadults,10-15%ofacutelymphoblasticleukemia(ALL),85-90%oflymphoblasticlymphoma(LBL),malepredominance(PediatrBloodCancer2008;51:489)MatureT/NKcellneoplasms:relativelyuncommon;15%ofnon-HodgkinlymphomasinU.S./WesternEurope;areusuallyaggressivewithmediansurvivalof10-30monthsLargeinternationalstudy(Blood1997;89:3909):12%ofallNHLareT/NKcell(peripheralTcelllymphomaNOS-25.9%,angioimmunoblasticTcelllymphoma-18.5%)Significantgeographicandracialincidencevariation:generallymorecommoninAsiaorAsianpopulations;adultTcellleukemia/lymphomainendemicHTLV-Iar