The skin is secondarily involved but a disease based primarily in the skin may also occur. Histology of extranodal NK/T cell lymphoma, nasal type. In extranodal​ ...DermNetprovidesGoogleTranslate,afreemachinetranslationservice.Notethatthismaynotprovideanexacttranslationinalllanguageslogo-newThispagewasprintedon7/7/2021HomeTopicsA–ZImagesBrowseDermDiagGlossaryQuizzesAboutContactJobsDonatebreadcrumbsHome»TopicsA–Z»ExtranodalNK/Tcelllymphoma,nasaltype,pathologyExtranodalNK/Tcelllymphoma,nasaltype,pathologyAuthor:AssocProfPatrickEmanuel,Dermatopathologist,Auckland,NewZealand,2013.ExtranodalNK/Tcelllymphoma,nasaltype,pathology—codesandconceptsopenSynonyms:AngiocentricTcelllymphomapathology,T/NKcelllymphomapathologyCategories:Pathology,Tumour,ViralinfectionSubcategories:RoleofEBVinextranodalNK/Tcelllymphoma,nasaltype,EpsteinBarrvirus,EBV-associatedlymphoproliferativedisorderICD-10:C86.0ICD-11:2A90.6SNOMEDCT:414166008,40168006IntroductionExtranodalNK/Tcelllymphoma,nasaltype,isanEpstein-Barrvirus(EBV)-drivendiseasewhichtypicallyprimarilyinvolvestheupperrespiratorytract(seeEpstein–Barrvirus-associatedlymphoproliferativedisorders).Theskinissecondarilyinvolvedbutadiseasebasedprimarilyintheskinmayalsooccur.HistologyofextranodalNK/Tcelllymphoma,nasaltypeInextranodalNK/Tcelllymphoma,nasaltype,thereisadensedermalinfiltrate(figure1)whichoftenextendsintothesubcutis.Exocytosisofatypicallymphocytesintotheepidermismaybeseenandmaycloselyresemblemycosisfungoides(figure2).Theinfiltrateinthedermisisusuallypolymorphousandmayincludenumeroushistiocytesandeosinophils.Theatypicalcellsaresmalltomediumsizedwithsomelargerforms(figures3,4).Commonly,theinfiltrateinfiltratesthewallsofvessels(figures3,4)causingvascularnucleardebris(seenfocallyinfigure4).Necrosisisanothercommonfinding.ExtranodalNK/Tcelllymphoma,nasaltypepathologyFigure1Figure2Figure3Figure4SpecialstudiesforextranodalNK/Tcelllymphoma,nasaltypeSpecialstainsareessentialformakingthediagnosis.In-situhybridizationwithEBVshowstheatypicalcells