Printable | NK/T cell lymphoma Pathology outlines

Surgical Pathology Criteria ... Extranodal NK/T Cell Lymphoma, Nasal Type ... Polymorphic extranodal lymphoma, expressing NK or rarely cytotoxic T cell ...SurgicalPathologyCriteriahttp://surgpathcriteria.stanford.edu/usebrowserbackbuttontoreturnExtranodalNK/TCellLymphoma,NasalTypeDefinitionPolymorphicextranodallymphoma,expressingNKorrarelycytotoxicTcellphenotypeAlternate/HistoricalNamesPolymorphicreticulosisLethalmidlinegranulomaAngiocentricTcelllymphomaDiagnosticCriteriaPrimarilyextranodalMostcommonsiteisnoseNodesmaybeinvolvedsecondarilyNecrosisnearlyalwayspresentVasculardestructionmaybeseenUlcerationcommonPseudoepitheliomatoushyperplasiamaybeseenWiderangeofappearancefromsmalltolargecellFrequentlymixedInflammatorycellsmaybeprominentCytoplasmmaybeclearwithazurophilicgranulesonGiemsastainedcytologicpreparationsCD56positiveRarecasesmaylackCD56,butmustthenbeEBV+,CD3+andcytotoxicprotein+EBVpositiveMaybelackinginsomeextranasal,NorthAmericanorWesternEuropeancasesNotethattheterm"nasaltype"originallyappliedonlytolymphomasofthistypethatoccurredinsitesotherthanthenasalcavity;itnowincludesnasalandextra-nasallocationsDitaGratzingerMDPhDYasodhaNatkunamMDPhDRobertVRouseMDDepartmentofPathologyStanfordUniversitySchoolofMedicineStanfordCA94305-5342Initialposting:September1,2007SupplementalstudiesImmunohistologyandFlowNKtypeCD56100%EBVLMPPositive,lesssensitivethaninsituhybridizationCD3Cytoplasmicpositive,membranenegativeCytotoxicgranuleproteins:granzymeB,TIA1,perforinGenerallypositiveCD43,CD45ROGenerallypositiveCD20,CD79aRarepositivecasesreportedCD30OccasionallypositiveCD4,CD5,CD8NegativeTcelltypeCD56NegativeCD3PositiveCD5,CD8MaybepositiveCytotoxicgranuleproteins:granzymeB,TIA1,perforinRequiredfordiagnosisEBVRequiredfordiagnosisCD56isnotspecific,itmaybeseeninotherlymphomasandnon-lymphoidneoplasmsGeneticanalysisEBVEBERpositivebyinsituhybridization25-95%DependsongeographiclocationInendemicareas95%CaseswithNKphenotypewillhavegermlineTcellreceptorgeneconfigurationDifferentialDiagnosisNon


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