Kleine-Levin Syndrome (KLS) is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, ...FacebookTwitterGoogleWhatisKLS?DefiningKLSKleine-LevinSyndrome(KLS)isarareandcomplexneurologicaldisordercharacterizedbyrecurringperiodsofexcessiveamountsofsleep,alteredbehavior,andareducedunderstandingoftheworld.Thedisorderstrikesadolescentsprimarilybutcanoccurinyoungerchildrenandadults.Attheonsetofanepisodethepatientbecomesprogressivelydrowsyandsleepsformostofthedayandnight(hypersomnolence),sometimeswakingonlytoeatorgotothebathroom.Eachepisodelastsdays,weeksormonthsduringwhichtimeallnormaldailyactivitiesstop.Individualsarenotabletocareforthemselvesorattendschoolandwork.Inbetweenepisodes,thosewithKLSappeartobeinperfecthealthwithnoevidenceofbehavioralorphysicaldysfunction.KLSepisodesmaycontinuefor10yearsormore.KLSissometimesreferredtointhemediaas“SleepingBeauty”syndrome.IdentifyingKLSInadditiontoexcessivesleep,aKleine-LevinSyndrome(KLS) patient’swholedemeanorischanged,oftenappearing“spacey”orchildlike.Whenawakethepatient experiencesconfusion,disorientation,completelackofenergy(lethargy),andlackofemotions(apathy).Mostpatientsreportthateverythingseemsoutoffocus,andthattheyarehypersensitivetonoiseandlight.Insomecases,foodcravings(compulsivehyperphagia)areexhibited.Instancesofuninhibitedhyper-sexualityduringanepisodehavealsobeenreported.Kleine-LevinSyndrome(KLS)episodesarecyclical.Whenpresent,KLSsymptomspersistfordays,weeksorevenmonths,duringwhichtimeallnormaldailyactivitiesstop.Individualsarenotabletoattendschool,workorcareforthemselves.Mostarebedridden,tiredanduncommunicativeevenwhenawake.NoteveryoneaffectedbyKLSexhibitsallofthesymptomsdescribedabove.Affectedindividualsmaygoforaperiodofweeks,monthsorevenyearswithoutexperiencinganysymptoms,andthensymptoms reappearwithlittlewarning.Inbetweenepisodes,thosediagnosedwithKLSappeartobeinperfecthealthwithnoevidenceofbehavioralorphysicaldysfunction.Howevertheyfunctiondail

Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterised by relapsing-remitting episodes of hypersomnia in association with ...xShareShareRarediseasesSearchClinicalSignsandSymptomsClassificationsGenesDisabilityEncyclopaediaforpatientsEncyclopaediaforprofessionalsEmergencyguidelinesSources/proceduresHomepageRarediseasesSearchSearchforararedisease*(*)mandatoryfieldSearchDiseasenameORPHAcodeOMIMICD-10GenenameorsymbolOthersearchoption(s)AlphabeticallistSuggestanupdate(*)Requiredfields.Youare(*)Choose:HealthprofessionalPatient/Family/AssociationBiopharmaceuticalindustryScientistStudentOtherIfyouhaveselectedthe“Other”category,pleasespecifywhichtypeofuseryouare:*Emailaddress:*Topicofyourcomment*EpidemiologydataSummaryandrelatedtextsRelatedgenesClinicalsignsNomenclatureand/orcodingYourmessage*(3000charactersremaining)AttentionOnlycommentsseekingtoimprovethequalityandaccuracyofinformationontheOrphanetwebsiteareaccepted.Forallothercomments,pleasesendyourremarksviacontactus.OnlycommentswritteninEnglishcanbeprocessed.CheckthisboxifyouwishtoreceiveacopyofyourmessagePleasereproducethetextbelow:*Kleine-LevinsyndromeDiseasedefinitionKleine-Levinsyndrome(KLS)isarareneurologicaldisorderofunknownorigincharacterisedbyrelapsing-remittingepisodesofhypersomniainassociationwithcognitiveandbehaviouraldisturbances.ORPHA:33543Classificationlevel:DisorderSynonym(s):-Prevalence:1-9/1000000Inheritance:-Ageofonset:Adolescent,Childhood,AdultICD-10:G47.8OMIM:148840UMLS:C0206085MeSH:D017593GARD:3117MedDRA:10053712SummaryEpidemiologyItaffectsaround1/500000individuals.Patientsaremostlymale(68-78%ofcases)andadolescents(81%ofpatients),withameanageofonsetof15years(range4-82years).ClinicaldescriptionThefirstepisodeistriggeredbyaninfectionin72%ofpatients.Patientsexperience7-19neurologicalepisodeswithadurationof10-13days/episodeandrelapsesevery3.5months.Onethirdofpatientshaveepisodeslastinglongerthanonemonth.Episodesrecurmorequicklyinpatientswithchildhoodonset.Duringepisod

Kleine–Levin syndrome (KLS) is a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also ...Kleine–LevinsyndromeFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchKleine–LevinsyndromeOthernamesFamilialhibernationsyndrome[1]SpecialtyNeurology Kleine–Levinsyndrome(KLS)isararedisordercharacterizedbypersistentepisodichypersomniaandcognitiveormoodchanges.Manypatientsalsoexperiencehyperphagia,hypersexualityandothersymptoms.Patientsgenerallyexperiencerecurrentepisodesoftheconditionformorethanadecadeandmayreturnatalaterage.Individualepisodesgenerallylastmorethanaweek,sometimeslastingformonths.Theconditiongreatlyaffectsthepersonal,professional,andsociallivesofsufferers.Theseverityofsymptomsandthecourseofthesyndromevarybetweensufferers.Patientscommonlyhaveabout20episodesoveraboutadecade.Severalmonthsgenerallyelapsebetweenepisodes.Theonsetoftheconditionusuallyfollowsaviralinfection;severaldifferentviruseshavebeenobservedtotriggerKLS.Itisgenerallyonlydiagnosedaftersimilarconditionshavebeenexcluded;MRI,CTscans,lumbarpuncture,andtoxicologytestsareusedtoruleoutotherpossibilities.Thesyndrome'smechanismisnotknown,butthethalamusisthoughttopossiblyplayarole.SPECThasshownthalamichypoperfusionofpatientsduringepisodes.KLSisveryrare,occurringatarateof1in1million,whichlimitsresearchintogeneticfactors.Theconditionprimarilyaffectsadolescentmales,thoughfemalescanalsobeaffectedandtheageofonsetvaries.Thereisnoknowncure,andthereislittleevidencesupportingdrugtreatment.Lithiumhasbeenreportedtohavelimitedeffectsincasereports,decreasingthelengthofepisodesanddurationbetweentheminsomepatients.[2]Stimulantshavebeenshowntopromotewakefulnessduringepisodes,buttheydonotcounteractcognitivesymptomsordecreasethedurationofepisodes.TheconditionisnamedafterWilliKleineandMaxLevin,[3]whodescribedcasesofthediseaseintheearly20thcentury.ItwasaddedtotheInternationalClassificationofSleepDisordersin1990.Contents1Symptoms2Cause3Diagnosis4Prevention5Treatm

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The 20-year-old from Stockport in Greater Manchester has Kleine-Levin Syndrome (KLS), also known as 'Sleeping Beauty' syndrome.mediacaptionBBCInsideOutmeetsayoungwomanwhoseextremelyrareillnesscauseshertosleepforweeksonendWhilemanyofusdreamofafewextrahours'sleepduetothepressuresofworkandfamily,suchanideaisthestuffofnightmaresforoneyoungwoman.Forduringepisodesofherextremelyrareillness,whichcanlastforweeks,BethGoodierisawakeforonlytwohoursaday.The20-year-oldfromStockportinGreaterManchesterhasKleine-LevinSyndrome(KLS),alsoknownas'SleepingBeauty'syndrome.ButlivingwithKLSisfarfrombeingafairytale,shesaysofhercondition,whichonlyaffectsaround40peopleintheUK,themajorityofwhomareteenageboys."It'snothingbeautiful,it'snothingromantic,it'shorrible."Child-likebehaviourExpertsdonotknowwhatcausesKLS,whosesymptomsfirstappearedinBethwhenshewas16,andthereisnoknowncure.Alongwithepisodesofextendedsleeping,theconditionalsotypicallycausesbehaviourchangessuchasfeelinginadream-likestate,actinginachild-likemanner,andbingeeating.Itbeginsinadolescenceandthoseaffectedjusthavetowaittogrowoutofitafterabout10-15years.imagecaptionJanineGoodierhashadtogiveupworktocareforherdaughterBethGoodierwhohasKleine-LevinSyndromeKLScanbeveryisolating,notleastbecauselifeandtimemovesonforthosearoundBethwhilstsheisconsumedbyanepisode.Butduringtheperiodswhensheiswell,sheuseshertimetoblogaboutKLSandexpressherselfthroughYouTubevideos."IwanttobeabletodosomethingproductiveinthetimewhenI'mwell...tobeproductiveforsociety,"shetellsBBCInsideOutNorthWest.Bethisentirelydependentonhermum,Janine,whohadtogiveupworktocareforher.imagecaptionDrGuyLeschziner,consultantneurologistatGuy'sHospitalinLondon,saysKLSisdevastatingforyoungpeoplewiththeconditionMrsGoodierexplainsthatexcessivesleepingisonlypartoftheproblembecausewhenawakeduringanepisode,herdaughterisinachild-likestateandconfusedaboutwhatisrealandwhatisadream."Whenshe'sup,allshedoesreallyis,she'seitherinbedoronthesofaandshe'llwatchtelly,oftenthesamethingsoverandoveragainassheli

Kleine-Levin service. The Lifespan Sleep Disorder Group at Guy's and St Thomas' provides specialist services for children and adults with rare disorders ...SkiptomaincontentIfyourchildhasbeeninvitedforaface-to-faceappointmentorprocedure,it’simportantyoustillcome(evenduringthenationallockdown)unlessyouhearotherwise.Tohelpkeepeveryonesafe,onlyoneparentorcarercanattend.Nootherfamilyorfriendscanvisit.SeeallourinformationaboutCOVID-19,includingstepswearetakingtokeepyousafe.NarcolepsyandKleine-LevinsyndromeCoronavirus(COVID-19)sleeptipsforfamiliesOverviewTeamConditionswetreatNarcolepsyandKleine-LevinsyndromeReferralsPatientsForprofessionalsWorkshopLondonPaediatricSleepGroupTheLifespanSleepDisorderGroupatGuy'sandStThomas' providesspecialistservicesforchildrenandadultswithraredisorderscharacterisedbyexcessivedaytimesleepiness(oftencalledhypersomnia).NarcolepsyandKleineLevinsyndromearetwoexamplesofdisorderswesee.Childrenandyoungpeoplewiththeconditionsarecaredforbyamultidisciplinaryteam(ateammadeupofdifferenthealthcareprofessionals),withsupportgroups,andschoolinput.At16theyarethenmovedsmoothlytoadultservicesthroughspecialtransitionalclinics.Pleaseseeourreferralspageifyou'dliketoreferanyonewithexcessivedaytimesleepiness.NarcolepsyandcataplexyWhatisit?Thisisararesleepdisorderwithirresistibleandunpredictabledaytimesleepattacksandanumberofothersymptoms.Cataplexy,uniquetonarcolepsy,isasuddenepisodeofmuscleweaknesstriggeredbyemotions.Typically,theperson’skneesbuckleandmaygivewayuponlaughing,surpriseoranger. Inothertypicalcataplecticattackstheheadmaydroporthejawmaybecomeslack.Cataplexyinchildrenisslightlydifferentandavarietyofsymptomsandmovementsincludingtongueprotrusionandinvoluntaryarmmovementshavebeendescribed.Asthesesymptomslooksimilartootherneurologicalmovementdisorders,it'scommontoexplorearangeofotherconditionsbeforethediagnosisofnarcolepsywithcataplexybecomesmorecertain.ClinicalservicesWe'reabusyservice,runningclinicsforover120childrenwithnarcolepsyandcataplexy.Wesharecarewit

NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListFrontNeurolv.5;2014PMC4069720FrontNeurol.2014;5:105.Publishedonline2014Jun25.doi: 10.3389/fneur.2014.00105PMCID:PMC4069720PMID:25009530FunctionalMagneticResonanceImaginginNarcolepsyandtheKleine–LevinSyndromeMariaEngström,1,2,*ToveHallböök,3AttilaSzakacs,3,4ThomasKarlsson,2,5andAnne-MarieLandtblom2,6,7,8MariaEngström1DivisionofRadiologicalSciences,DepartmentofMedicalandHealthSciences(IMH),LinköpingUniversity,Linköping,Sweden2CenterforMedicalImageScienceandVisualization(CMIV),LinköpingUniversity,Linköping,SwedenFindarticlesbyMariaEngströmToveHallböök3DepartmentofPediatrics,InstituteofClinicalSciences,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,SwedenFindarticlesbyToveHallböökAttilaSzakacs3DepartmentofPediatrics,InstituteofClinicalSciences,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,Sweden4DepartmentofPediatrics,HalmstadCountyHospital,Halmstad,SwedenFindarticlesbyAttilaSzakacsThomasKarlsson2CenterforMedicalImageScienceandVisualization(CMIV),LinköpingUniversity,Linköping,Sweden5DivisionofDisabilityResearchandLinnaeusCentreHEAD,DepartmentofBehavioralScienceandLearning,LinköpingUniversity,Linköping,SwedenFindarticlesbyThomasKarlssonAnne-MarieLandtblom2CenterforMedicalImageScienceandVisualization(CMIV),LinköpingUniversity,Linköping,Sweden6DepartmentofNeurology,DepartmentofClinicalandExperimentalMedicine(IKE),LinköpingUniversity,Linköping,Sweden7DepartmentofMedicalSpecialist,DepartmentofMedicineandHealthSciences,LinköpingUniversity,Motala,Sweden8DepartmentofNeuroscience,UppsalaUniversity,Uppsala,SwedenFindarticlesbyAnne-MarieLandtblomAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimer1DivisionofRadiologicalSciences,DepartmentofMedicalandHealthSciences(IMH),LinköpingUniversity,Linköping,Sweden2CenterforMedicalImageScienceandVisualization(CMIV),LinköpingUniversity,Linköping,Sweden3DepartmentofPediatrics,InstituteofClinicalSciences,Sahlg

SkiptomaincontentSubmitSearchCOVID-19Getthelatestfunding,research,andpublichealthinformationfromNINDSGetthelatestresearchinformationfromNIH|EspañolGetthelatestpublichealthinformationfromHHSGetthelatestpublichealthinformationfromCDCYouarehereHome»Disorders»AllDisordersKleine-LevinSyndromeInformationPageKleine-LevinSyndromeInformationPageWhatresearchisbeingdone?NINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisorders×Whatresearchisbeingdone?NINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisordersSeeMoreAboutResearchNINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisordersShowMoreShowLessSearchDisordersSEARCHDefinitionTreatmentPrognosisClinicalTrialsOrganizationsPublicationsDefinitionKleine-Levinsyndromeisararedisorderthatprimarilyaffectsadolescentmales(approximately70percentofthosewithKleine-Levinsyndromearemale).Itischaracterizedbyrecurringbutreversibleperiodsofexcessivesleep(upto20hoursperday).Symptomsoccuras"episodes,"typicallylastingafewdaystoafewweeks.Episodeonsetisoftenabrupt,andmaybeassociatedwithflu-likesymptoms.Excessivefoodintake,irritability,childishness,disorientation,hallucinations,andanabnormallyuninhibitedsexdrivemaybeobservedduringepisodes.Moodcanbedepressedasaconsequence,butnotacause,ofthedisorder.Affectedindividualsarecompletelynormalbetweenepisodes,althoughtheymaynotbeabletorememberafterwardseverythingthathappenedduringtheepisode.Itmaybeweeksormorebeforesymptomsreappear.Symptomsmayberelatedtomalfunctionofthehypothalamusa

Kleine-Levin syndrome (KLS) is a rare disorder that causes recurring periods of excessive sleepiness. In some cases, this means up to 20 hours a day are spent ...WhatIsKleine-LevinSyndrome(KLS)?MedicallyreviewedbyRickyChen,M.D.—WrittenbyValenciaHiguera—UpdatedonNovember14,2018SymptomsCausesandriskfactorsDiagnosisManagementCopingOutlookKLSisalsoknownas“sleepingbeautysyndrome”Kleine-Levinsyndrome(KLS)isararedisorderthatcausesrecurringperiodsofexcessivesleepiness.Insomecases,thismeansupto20hoursadayarespentsleeping.Forthisreason,theconditioniscommonlyreferredtoas“sleepingbeautysyndrome.”KLScanalsoproducechangesinbehaviorandconfusion.Thisdisordercanaffectanyone,butteenageboysdeveloptheconditionmorethananyothergroup.About70percentofpeoplewiththisdisorderaremale.Episodescancomeandgooveranextendedperiodoftime.Sometimesthey’reonandoffforaslongas10years.Duringeachepisode,itcanbedifficulttoattendschool,work,orparticipateinotheractivities.Whatarethesymptoms?PeoplelivingwithKLSmaynotexperiencesymptomseveryday.Infact,affectedindividualstypicallydon’thaveanysymptomsbetweenepisodes.Whensymptomsdoappear,theycanlastafewdays,weeks,orevenmonths.Commonsymptomsincludeextremesleepiness.Theremaybeastrongdesiretogotobedandtroublegettingupinthemorning.Duringanepisode,it’snotuncommontosleepupto20hoursaday.PeoplelivingwithKLSmaygetuptousethebathroomandeat,thengobacktosleep.FatiguecanbesoseverethatpeoplewithKLSarebedriddenuntilanepisodepasses.Thistakestimeandenergyawayfromfamily,friends,andpersonalobligations.Episodescanalsotriggerothersymptoms,suchas:hallucinationsdisorientationirritabilitychildishbehaviorincreasedappetiteexcessivesexdriveThismayresultfromreducedbloodflowtopartsofthebrainduringanepisode.KLSisanunpredictablecondition.Episodescanrecursuddenlyandwithoutwarningweeks,months,oryearslater.Mostpeopleresumenormalactivityafteranepisodewithoutanybehavioralorphysicaldysfunction.However,theymayhavelittlememoryofwhathappenedduringtheirepisode.WhatcausesKLSandwho’satrisk?TheexactcauseofKLSi

. Kleine‐Levin syndrome (KLS) is a rare disorder that mainly affects.SearchresultsJumptosearchresultsFilterTogglefilterpanelEvidencetypeAddfilterforGuidanceandPolicy(2)AddfilterforGuidance(2)AddfilterforSecondaryEvidence(2)AddfilterforSystematicReviews(1)AddfilterforEvidenceSummaries(1)SourceAddfilterforCochraneDatabaseofSystematicReviews(1)AddfilterforOrphanet(1)FilterbyDateFilterresultsbydate:FromEnterdateintheformatyyyy-mm-ddToEnterdateintheformatyyyy-mm-ddApplydatefilter4resultsforKleinelevinsyndromeSortedbyRelevance.|SortbyDateShowingresults1to4.Viewoptionsfordownloadingtheseresults.AddthisresulttomyexportselectionPharmacologicaltreatmentforKleine‐LevinsyndromeSource:CochraneDatabaseofSystematicReviews(Addfilter)06May2016versionoftheoriginalCochranereview,publishedin2009,Issue2.Kleine‐Levinsyndrome(KLS)isararedisorderthatmainlyaffects...Type:SystematicReviews(Addfilter)AddthisresulttomyexportselectionKleineLevinsyndromeSource:Orphanet(Addfilter)thesurveyxOrphanet:KleineLevinsyndromeType:EvidenceSummaries(Addfilter)AddthisresulttomyexportselectionAustralasianSleepAssociationclinicalpracticeguidelinesforperformingsleepstudiesinchildren(PDF)PublishedbyAustralasianSleepAssociation,01August2017Thisclinicalpracticeguideline,intendedforusebypaediatricrespiratoryandsleeppractitioners,providesbestpracticerecommendationsforconductingpaediatricsleepstudiesinAustraliaand...ReadSummaryType:Guidance(Addfilter)AddthisresulttomyexportselectionCanadianclinicalpracticeguidelinesforthemanagementofanxiety,posttraumaticstressandobsessive-compulsivedisorders(PDF)PublishedbyCanadianMedicalAssociation,01July2014Anxietyandrelateddisordersareamongthemostcommonmentaldisorders,butareunder-diagnosedandunder-treated.Theyare:verycommoninclinicalpractice,andfrequentlycomorbidwithother...ReadSummaryType:Guidance(Addfilter)DownloadresultsClickexportCSVorRIStodownloadtheentirepageofresultsorusethecheckboxineachresulttoselectasubsetofrecordstodownload.ExportaCSVfileExportaRISfilePage1of1Resultspe