Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Major clinical manifestation of human SFTS infection is high fever, ... organs are the primary target of the virus at the end stage of lethal SFTSV infection. ... Severe fever with thrombocytopenia syndrome virus targets B cells in ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.Advertisementnatureexperimental&molecularmedicinereviewarticlesarticleSeverefeverwiththrombocytopeniasyndromevirus:emergingnovelphlebovirusandtheircontrolstrategyDownloadPDFSubjectsInfectionViralinfectionAbstractAnemerginginfectiousdiseasefirstidentifiedincentralChinain2009,severefeverwiththrombocytopeniasyndrome(SFTS)wasfoundtobecausedbyanovelphlebovirus.SinceSFTSVwasfirstidentified,epidemicshaveoccurredinseveralEastAsiancountries.WiththeescalatingincidenceofSFTSandtherapid,worldwidespreadofSFTSVvector,itisclearthisvirushaspandemicpotentialandpresentsanimpendingglobalpublichealththreat.Inthisreview,weconciselysummarizethelatestfindingsregardingSFTSV,includingvectorandvirustransmission,genotypediversityandepidemiology,probablepathogenicmechanism,andclinicalpresentationofhumanSFTS.TicksmostlikelytransmitSFTSVtoanimalsincludinghumans;however,human-to-humantransmissionhasbeenreported.Themajorityofarbovirustransmissioncycleincludesvertebratehosts,andpotentialreservoirsincludeavarietyofbothdomesticandwildanimals.ReportsoftheseroprevalenceofSFTSVinbothwildanddomesticanimalsraisestheprobabilitythatdomesticanimalsactasamplifyinghostsforthevirus.MajorclinicalmanifestationofhumanSFTSinfectionishighfever,thrombocytopenia,leukocytopenia,gastrointestinalsymptoms,andahighcase-fatalityrate.Severalanimalmodelsweredevelopedtofurtherunderstandthepathogenesisofthevirusandaidinthediscoveryoftherapeuticsandpreventivemeasures.DownloadPDFIntroductionTheseverefeverwith
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