Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections

Severe fever with thrombocytopenia syndrome virus targets B cells in lethal ... Asia, the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully ...搜索当前位置：X-MOL学术›J.Clin.Invest.›论文详情SeverefeverwiththrombocytopeniasyndromevirustargetsBcellsinlethalhumaninfections.TheJournalofClinicalInvestigation(IF11.864)PubDate : 2020-02-03,DOI:10.1172/jci129171TadakiSuzuki,YukoSato,KaoriSano,TakeshiArashiro,HarutakaKatano,NorikoNakajima,MasayukiShimojima,MichiyoKataoka,KentaTakahashi,YujiWada,ShigeruMorikawa,ShuetsuFukushi,TomokiYoshikawa,MasayukiSaijo,HidekiHasegawaSeverefeverwiththrombocytopeniasyndrome(SFTS)isanemerginghemorrhagicfevercausedbyatick-bornebanyangvirusandisassociatedwithhighfatality.DespiteincreasingincidenceofSFTSandseriouspublichealthconcernsinEastAsia,thepathogenesisoflethalSFTSvirus(SFTSV)infectioninhumansisnotfullyunderstood.Numbersofpostmortemexaminationstodeterminetargetcellsoftheviralinfectionhavesofarbeenlimited.HereweshowedthatBcellsdifferentiatingintoplasmablastsandmacrophagesinsecondarylymphoidorgansweretargetsforSFTSVattheendstageoflethalinfection,andthemajorityofSFTSV-infectedcellswereBcell-lineagelymphocytes.Inaffectedindividuals,Bcell-lineagelymphocyteswithSFTSVinfectionwerewidelydistributedinbothlymphoidandnonlymphoidorgans,andinfiltrationofthesecellsintothecapillariesoftheorganscouldbeobservedoccasionally.Moreover,ahumanplasmablasticlymphomacellline,PBL-1,wassusceptibletoSFTSVpropagationandhadasimilarimmunophenotypetothatoftargetcellsofSFTSVinfatalSFTS.PBL-1canthereforeprovideapotentialinvitromodelforhumanSFTSVinfection.TheseresultsextendourunderstandingofthepathogenesisofhumanlethalSFTSVinfectionandcanfacilitatethedevelopmentofSFTSVcountermeasures.中文翻译：血小板减少综合症病毒引起的严重发烧针对致命的人类感染中的B细胞。

血小板减少症候群（SFTS）的重度发烧是由tick传播的山阳病毒引起的新兴出血热，并伴有高死亡率。

尽管在东亚，SFTS的发病率增加并且引起了严重的公共卫生问题，但人类对致命SFTS病毒（SFTSV）感染的发病机理尚未完全了解。

迄今为止，用于确定病毒感染靶细胞的验尸检查的数量受到限制。

在这里，我们显示在致死性感染的末期，分化为次生淋巴器官的浆母细胞和巨噬细胞的B细胞是SFTSV的靶标，大多数SFTSV感染的细胞是B细胞谱系淋巴

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