Severe fever with thrombocytopenia syndrome virus targets B ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections

... syndrome virus targets B cells in lethal human infections | Severe fever with ... the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully ...HomeLymphocytesHemocytesLeukocytesBiologicalScienceCellBiologyCellTypeBCellsArticleSeverefeverwiththrombocytopeniasyndromevirustargetsBcellsinlethalhumaninfectionsJanuary2020JournalofClinicalInvestigation130(11)DOI:10.1172/JCI129171Authors:TadakiSuzukiNationalInstituteofInfectiousDiseases,TokyoYukoSatoFraunhoferInstituteforAppliedInformationTechnologyFITKaoriSanoKaoriSanoThispersonisnotonResearchGate,orhasn'tclaimedthisresearchyet.TakeshiArashiroTakeshiArashiroThispersonisnotonResearchGate,orhasn'tclaimedthisresearchyet.Showall15authorsHideRequestfull-textPDFToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Requestfull-textDownloadcitationCopylinkLinkcopiedRequestfull-textDownloadcitationCopylinkLinkcopiedToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Citations(21)References(61)AbstractSeverefeverwiththrombocytopeniasyndrome(SFTS)isanemerginghemorrhagicfevercausedbyatick-bornebanyangvirusandisassociatedwithhighfatality.DespiteincreasingincidenceofSFTSandseriouspublichealthconcernsinEastAsia,thepathogenesisoflethalSFTSvirus(SFTSV)infectioninhumansisnotfullyunderstood.Numbersofpostmortemexaminationstodeterminetargetcellsoftheviralinfectionhavesofarbeenlimited.HereweshowedthatBcellsdifferentiatingintoplasmablastsandmacrophagesinsecondarylymphoidorgansweretargetsforSFTSVattheendstageoflethalinfection,andthemajorityofSFTSV-infectedcellswereBcell-lineagelymphocytes.Inaffectedindividuals,Bcell-lineagelymphocyteswithSFTSVinfectionwerewidelydistributedinbothlymphoidandnonlymphoidorgans,andinfiltrationofthesecellsintothecapillariesoftheorganscouldbeobservedoccasionally.Moreover,ahumanplasmablasticlymphomacellline,PBL-1,wassusceptibletoSFTSVpropagation,andhadasimilarimmunophenotypetothatoftargetcellsofSFTSVinfatalSFTS.PBL-1canthereforeprovideapotentialinvitromod

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A new emerging pandemic of severe fever with ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Vertebrates are the host of this disease and tick functions as a vector, where the virus ... In china, during 2013 to 2016, total 7419 cases of human have been ... First case of SFTS in North Korea was reported in 2009 [28] and fatal case ... Severe fever with thrombocytopenia syndrome virus targets B cells in ...
Severe fever with thrombocytopenia syndrome virus (SFTSV ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Original Research Severe fever with thrombocytopenia syndrome virus ... IL-1β secretion in the infected human peripheral blood mononuclear cells (PBMCs), human ... Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection ... IbaI-positive macrophages and Pax5-positive immature B cells overlapped ...
Molecular Signatures of Inflammatory Profile and B-Cell ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Dabie bandavirus (severe fever with thrombocytopenia syndrome virus ... both human and SFTSV sequences, allowed us to identify cells that harbor ... cells, as one of the potential viral targets in blood of fatal SFTSV infection.
Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Severe fever with thrombocytopenia syndrome virus targets B cells in lethal ... Asia, the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully ...
Severe fever with thrombocytopenia syndrome virus | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious ... syndrome virus targets B cells in lethal human infections.
Severe fever with thrombocytopenia syndrome virus targets B ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
... syndrome virus targets B cells in lethal human infections | Severe fever with ... the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully ...
Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Major clinical manifestation of human SFTS infection is high fever, ... organs are the primary target of the virus at the end stage of lethal SFTSV infection. ... Severe fever with thrombocytopenia syndrome virus targets B cells in ...
SFTSV-infected B cells infiltrate nonlymphoid organs in ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections ... Citation Information: J Clin Invest. 2020;130(2):799 ...
Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections. Tadaki Suzuki,1 Yuko Sato,1 Kaori Sano,1,2 ...
Severe fever with thrombocytopenia syndrome virus ... | Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections. J Clin Invest. 2020 Feb 3;130(2):799-812. doi: 10.1172/JCI129171 ...