AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Bone&joints>Ewingsarcoma/PNETBone&jointsUndifferentiated/poorlydifferentiatedsmallround/spindlecelltumorEwingsarcoma/PNETAuthor: ErdenerÖzer,M.D.,Ph.D.TopicCompleted:1April2017Minorchanges:9February2021Copyright:2003-2021,PathologyOutlines.com,Inc.PubMedsearch:ewingsarcoma[title]bonePageviewsin2020:43,294Pageviewsin2021todate:15,414TableofContentsDefinition/general|Terminology|Epidemiology|Sites|Pathophysiology|Clinicalfeatures|Diagnosis|Radiologydescription|Radiologyimages|Prognosticfactors|Casereports|Treatment|Grossdescription|Grossimages|Microscopic(histologic)description|Microscopic(histologic)images|Cytologyimages|Positivestains|Negativestains|Molecular/cytogeneticsdescription|Molecular/cytogeneticsimages|Differentialdiagnosis|AdditionalreferencesCitethispage:ÖzerE.Ewingsarcoma/PNET.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/boneewing.html.AccessedApril13th,2021.Definition/generalEwingsarcoma(ES)andperipheralprimitiveneuroectodermaltumor(PNET)comprisethesamespectrumofneoplasticdiseasesknownastheEwingsarcomafamilyoftumors(EFT),whichalsoincludesmalignantsmallcelltumorofthechestwall(Askintumor)andatypicalESJamesEwing(1866-1943)firstdescribedthetumorRelatedtopicsatthesesites:softtissue,mediastinum,ovary,testisTerminologyEwingsarcomafamilyoftumors(PediatrDevPathol2012;15:108)EwingsarcomaAtypicalEwingsarcomaPrimitiveneuroectodermaltumor(PNET)AskintumorEpidemiologyTypicallyfoundinpatients5-25yearsofageSecondmostcommonmalignantbonetumorinchildrenSitesParticularlycommonlocationsincludetheparaspinaltissues,pelvis,chestwallandextremitiesMostcommonbonelocationsarepelvis,distalfemur,proximaltibia,femoraldiaphysisandprox