Ewing's sarcoma/PNET is a prototype of the “small round cell” tumor group. It is composed of sheets of small cells with high nuclear to cytoplasmic ratio. The cytoplasm is scant, eosinophilic, and usually contains glycogen, which is detected by periodic acid Schiff stain and is diastase degradable.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListIndianJOrthopv.44(4);Oct-Dec2010PMC2947721IndianJOrthop.2010Oct-Dec;44(4):363–368.doi: 10.4103/0019-5413.69304PMCID:PMC2947721PMID:20924475PathologyofEwing’ssarcoma/PNET:CurrentopinionandemergingconceptsSaralSDesaiandNirmalaAJambhekarSaralSDesaiDepartmentofPathology,TataMemorialHospital,Dr.ErnestBorgesRoad,Parel,Mumbai,Maharashtra,IndiaFindarticlesbySaralSDesaiNirmalaAJambhekarDepartmentofPathology,TataMemorialHospital,Dr.ErnestBorgesRoad,Parel,Mumbai,Maharashtra,IndiaFindarticlesbyNirmalaAJambhekarAuthorinformationCopyrightandLicenseinformationDisclaimerDepartmentofPathology,TataMemorialHospital,Dr.ErnestBorgesRoad,Parel,Mumbai,Maharashtra,IndiaAddressforcorrespondence:Dr.NirmalaJambhekar,DepartmentofPathology,TataMemorialHospital,Parel,Mumbai-400012,Maharashtra,India.E-mail:moc.liamg@iasedlarasCopyright©IndianJournalofOrthopaedicsThisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.ThisarticlehasbeencitedbyotherarticlesinPMC.Ewing’ssarcoma/PNETaresmallroundcelltumorsshowingavaryingdegreeofneuroectodermaldifferentiation.Theyareoneofthecommonesttumorsofchildhoodandoccurinboneandwithinsofttissues.Traditionally,lightmicroscopywiththeaidofimmunohistochemicalstainswassuitablefordiagnosis.Butnowtranslocationanalysesarebeingusednotonlyforthediagnosisandclassificationofsmallroundcelltumors,buttoascertaintheirprognosticsignificance,detectmicrometastasis,andmonitorminimalresidualdisease,withpotentialfortargetedtherapy.Thisarticleanalyzes