Neural and neuroectodermal differentiation was demonstrated in cell lines [4, 5] and tissue sections [6, 7], and tumors with the histology of Ewing sarcomas were ...Sarcoma+JournalMenuPDFJournaloverviewForauthorsForreviewersForeditorsTableofContentsSpecialIssuesSubmitSarcoma/2011/ArticleArticleSectionsOnthispageAbstractIntroductionConclusionsReferencesCopyrightReviewArticle|OpenAccessVolume2011|ArticleID856190|https://doi.org/10.1155/2011/856190AlfredoPinto,PaulDickman,DavidParham,"PathobiologicMarkersoftheEwingSarcomaFamilyofTumors:StateoftheArtandPredictionofBehaviour",Sarcoma,vol.2011,ArticleID856190,15pages,2011.https://doi.org/10.1155/2011/856190ShowcitationPathobiologicMarkersoftheEwingSarcomaFamilyofTumors:StateoftheArtandPredictionofBehaviourAlfredoPinto,1PaulDickman,2,3andDavidParham41CalgaryLaboratoryServices,UniversityofCalgary,AlbertaChildren'sHospital,2888ShaganappiTrailNW,Calgary,AB,Canada2DepartmentofPathology,PhoenixChildren'sHospital,1919E.ThomasRoad,Phoenix,AZ85016,USA3DepartmentsofPathologyandPediatrics,UniversityofArizona,CollegeofMedicine,Phoenix,AZ85016,USA4HealthSciencesCenter,UniversityofOklahoma,OklahomaCity,OK73104,USAShowmoreAcademicEditor:R.PollockReceived06Jul2010Revised20Sep2010Accepted23Sep2010Published14Oct2010Overthepastthreedecades,theoutcomeofEwingsarcomafamilytumor(ESFT)patientswhoarenonmetastaticatpresentationhasimprovedconsiderably.Theprognosisofpatientswithmetastaticdiseaseatthetimeofdiagnosisandrecurrenceaftertherapyremainsdismal.Drug-resistantdiseaseatdiagnosisoratrelapseremainsamajorcauseofmortalityamongpatientsdiagnosedwithESFT.Inordertoimprovetheoutcomeforpatientswithpotentialrelapse,thereisanurgentneedtofindreliablemarkersthateitherpredicttumorbehaviouratdiagnosisoridentifytherapeuticmoleculartargetsatthetimeofrecurrence.AnimprovedunderstandingofthecelloforiginandthemolecularpathwaysthatregulatetumorigenicityinESFTshouldaidusinthesearchfornoveltherapiesforESFT.Thepurposeofthispaperisthustooutlinecurrentconceptsofsarcomage