HealthConditionsDiscoverPlanConnectSubscribeWhatIsB-CellLymphoma?MedicallyreviewedbyYaminiRanchod,Ph.D.,M.S.—WrittenbyAnnPietrangelo—UpdatedonMarch12,2020SubtypesSymptomsTreatmentComplicationsRecoveryOutlookOverviewLymphomaisatypeofcancerthatbeginsinlymphocytes.Lymphocytesarecellsintheimmunesystem.Hodgkin’sandnon-Hodgkin’slymphomaarethetwomainkindsoflymphoma.T-celllymphomaandB-celllymphomaaretwotypesofnon-Hodgkin’slymphoma.There’salsoararetypecalledNK-celllymphoma.Amongpeoplewithnon-Hodgkinlymphoma,about85percenthaveB-celllymphoma.TreatmentforB-celllymphomasisbasedonthespecificsubtypeandstageofdisease.WhatarethesubtypesofB-celllymphoma?TherearemanysubtypesofB-celllymphoma,bothslowgrowing(indolent)andfastgrowing(aggressive),including:B-cellsubtypeCharacteristicsDiffuselargeB-celllymphoma(DLBCL)Thisisthemostcommontypeofnon-Hodgkin’slymphoma.It’sanaggressivebuttreatablecancerthatcaninvolvelymphnodesandotherorgans.FollicularlymphomaThisisthesecondmostcommontypeonnon-Hodgkin’slymphoma.It’sslowgrowingandusuallystartsinthelymphnodes.MantelcelllymphomaGenerallyinvolveslymphnodes,bonemarrow,spleen,andthegastrointestinalsystem.Chroniclymphocyticleukemia(CLL)/Smalllymphocyticlymphoma(SLL)Thistypeisindolentandtypicallyaffectsthebloodandbonemarrow(CLL),orlymphnodesandspleen(SLL).PrimarycentralnervoussystemlymphomaThistypeusuallystartsinthebrainorspinalcord.It’sassociatedwithimmuneproblemscausedbyAIDSoranti-rejectionmedicationsusedfollowingorgantransplantation.SplenicmarginalzoneB-celllymphomaThisisaslow-growingtypethatbeginsinthespleenandbonemarrow.ExtranodalmarginalzoneB-celllymphomaofMALTThistypeusuallyinvolvesthestomach.Itcanalsooccurinthelungs,skin,thyroid,salivarygland,oreye.NodalmarginalzoneB-celllymphomaThisisarare,slow-growingtypefoundmainlyinthelymphnodes.BurkittlymphomaThisisafast-growingtypethatismorecommoninchildren.HairycellleukemiaThisisaslow-growingtypethataffectsthespleen,lymphnodes,andblood.Lymphoplasmacyticlymphoma(Waldenstrommacroglobulinemia)Thisisarare,aslow