Extranodal marginal zone B-cell lymphoma, also known as mucosa-associated lymphoid tissue (MALT) lymphoma: This is the most common type of ...Whatpatientsandcaregiversneedtoknowabout cancer,coronavirus,andCOVID-19.CloseCriticalAlertBannerSearchVerenespañol|Downloadthistopic[PDF]AboutNon-HodgkinLymphomaWhatIsNon-HodgkinLymphoma?TypesofB-cellLymphomaTypesofT-cellLymphomaKeyStatisticsforNon-HodgkinLymphomaWhat’sNewinNon-HodgkinLymphomaResearchandTreatment?CancerA-ZNon-HodgkinLymphomaAboutNon-HodgkinLymphomaTypesofB-cellLymphomaB-celllymphomasmakeupmost(about85%)ofthenon-Hodgkinlymphomas(NHL)intheUnitedStates.ThesearetypesoflymphomathataffectBlymphocytes.ThemostcommontypesofB-celllymphomasarelistedbelow.DiffuselargeB-celllymphoma(DLBCL)ThisisthemostcommontypeofNHLintheUnitedStates,accountingforabout1outofevery3lymphomas.Thelymphomacellslookfairlylargewhenseenwithamicroscope. DLBCLcanaffectpeopleofanyage,butitoccursmostlyinolderpeople.Theaverageageatthetimeofdiagnosisismid-60s.Itusuallystartsasaquicklygrowingmassinalymphnodedeepinsidethebody,suchasinthechestorabdomen,orinalymphnodeyoucanfeel,suchasintheneckorarmpit.Itcanalsostartinotherareassuchastheintestines,bones,oreventhebrainorspinalcord.DLBCLtendstobeafast-growing(aggressive)lymphoma,butitoftenrespondswelltotreatment.Overall,about3outof4peoplewillhavenosignsofdiseaseaftertheinitialtreatment,andmanyarecured.AsubtypeofDLBCLisprimarymediastinalB-celllymphoma.Thistypeoflymphomaoccursmostlyinyoungwomen.Itstartsinthemediastinum(theareainthemiddleofthechestbehindthebreastbone).Itcangrowquitelargeandcancausetroublebreathingbecauseitoftenpressesonthewindpipe(trachea)leadingintothelungs.Itcanalsoblockthesuperiorvenacava(thelargeveinthatreturnsbloodtotheheartfromthearmsandhead),whichcanmakethearmsandfaceswell.Thisisafast-growinglymphoma,butitusuallyrespondswelltotreatment. ThereareseveralothersubtypesofDLBCL,butthesearerare.FollicularlymphomaAbout1outof5lymphomasintheUnitedStatesisafollicularlymphoma.Thisisusuallyaslow-growin