Diagnostic Workup of Small B Cell Lymphomas: A Laboratory | Small B-cell lymphoma

Lymphoma+JournalMenuPDFTableofContentsSubmitLymphoma/2012/ArticleArticleSectionsOnthispageAbstractIntroductionAbbreviationsSupplementaryMaterialsReferencesCopyrightReviewArticle|OpenAccessVolume2012|ArticleID346084|https://doi.org/10.1155/2012/346084KathrynRizzo,MehdiNassiri,"DiagnosticWorkupofSmallBCellLymphomas:ALaboratoryPerspective",Lymphoma,vol.2012,ArticleID346084,15pages,2012.https://doi.org/10.1155/2012/346084ShowcitationDiagnosticWorkupofSmallBCellLymphomas:ALaboratoryPerspectiveKathrynRizzo1andMehdiNassiri21DepartmentofPathology,ProfessionalPathologyServices,1ScienceCourt,Suite200,Columbia,SC29203,USA2DepartmentsofPathologyandLaboratoryMedicine,IndianaUniversitySchoolofMedicine,IndianaUniversityHealthPathologyLaboratory,350W.11thStreetIUHPL5044,Indianapolis,IN46202,USAShowmoreAcademicEditor:JanDelabieReceived11Aug2012Accepted25Sep2012Published20Nov2012SmallBcelllymphomaisamorphologicaldesignationtoagroupofBcelllymphomaswhicharecomposedofaclonalpopulationofsmalllymphoidcells.Thesubtypesofthiscategoryhavediagnosticallydistinctcharacteristicsanddifferentclinicalbehaviorsandtreatment.Correctdiagnosisandclassificationofthesesubsetsdependontheintegrationofmorphologic,immunophenotypic,andmoleculargeneticfeatures.Inthispaper,differentialdiagnosisofthiscategoryoftumorsandapracticalapproachbasedonbiomarkerevaluationarediscussed.1.IntroductionDiagnosisoflymphoidneoplasmshasbeendrasticallychangedduringthelastthreedecades.Ithadtransitionedovertheyearsfromapurelymorphology-basedapproach[1]toasystemthatintegratesimmunologicandmolecularbiologyfindings.ThecurrentWorldHealthOrganization(WHO)classification[2]isbasedonaconstellationofclinical,morphologic,immunophenotypic,andmoleculargeneticfeatures.IntheWHOclassification,lymphoidmalignanciesarecategorizedbasedontheirontogenytoBorTcells.IntheBlymphocytegroup,twomajorcategoriesarerecognized:precursorandmatureBlymphocytes.AmongmatureBcelllymphomaneoplasms,thosecomposedofsmalllymphoidcellsarecommonandhaveoverlappingfeatures,thusd

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