甲氟喹及青蒿素對伯氏瘧原蟲的療效 | 夏氏瘧原蟲
【摘要】 用4天抑制試驗法給感染伯氏瘧原蟲ANKA株小鼠灌胃咯萘啶12.5mg/kg·d或阿莫地喹25mg/kg·d均能完全殺滅原蟲;甲氟喹25mg/kg·d或青蒿素100mg/kg·d雖有抑制作用但 ...CNKI主頁|下載閱讀器|登錄中國期刊全文數據庫(世紀期刊)節點文獻咯萘啶、阿莫地喹、甲氟喹及青蒿素對伯氏瘧原蟲的療效THEBLOODSCHIZONTOCIDALEFFECTSOFPYRONARIDINE,AMODIAQUINE,MEFLOQUINEANDQINGHAOSUONMICEINFECTEDWITHPLASMODIUMBERGHBI推薦CAJ下載PDF下載不支持迅雷等下載工具，請取消加速工具後下載。
【作者】葉秀玉；邵葆若；儲言紅；【Author】YeXiu-Yu,ShaoBao-Ruo,ChuYan-HongInstituteofParasiticDiseases,ChineseAcademyofPreventiveMedicine,Shanghai200025【機構】中國預防醫學科學院寄生蟲病研究所；中國預防醫學科學院寄生蟲病研究所上海200025；上海200025；上海200025；【摘要】用4天抑制試驗法給感染伯氏瘧原蟲ANKA株小鼠灌胃咯萘啶12.5mg/kg·d或阿莫地喹25mg/kg·d均能完全殺滅原蟲;甲氟喹25mg/kg·d或青蒿素100mg/kg·d雖有抑制作用但治愈率僅為50％及0％。
咯萘啶12.5mg/kg·d對中度抗氯喹的NS系原蟲亦有明顯作用,洽愈率70％,而阿莫地喹100mg/kg·d、甲氟喹100mg/kg·d及青蒿素200mg/kg·d均無治愈鼠,示后3種藥與氯喹有不同程度的交叉抗性。
上述劑量的阿莫地喹、甲氟喹和青蒿素對高度抗咯萘啶的伯氏瘧原蟲無明顯抑制作用,示它們與咯萘啶有交叉抗性。
更多還原【Abstract】TheasexualstagesofP.bergheiANKAwerecompletelyeliminatedasrevealedina"4-daysuppressivetest"withthedailydoseofpyronaridine12.5mgbase/kgoramodiaquine25mgbase/kg.Mefloquine25mgbase/kgandqinghaosu100mg/kgthoughexertedobvioussuppressiveeffect,thecurerateswereonly50%and0%,respectively.Intreatingchloroquine-sensitiveP.bergheiANKAstrainpyronaridineexhibitedthebesttherapeuticactivity,whichwasfollowedbyamodiaquine,mefloquineandqinghaosu.Intreatingmoderatelychloroquine-resistantP.bergheiNSlinethecurerateofpyronaridine12.5mg/kg·d×4was70%,butnoneofthe10infectedmicefromanygroupwascuredbyamodiaquine100mg/kg2d,mefloquine100mg/kg·dorqinghaosu200mg/kg·d.Thoughthelatter3drugsshowedprominentsuppressiveeffects,parasitemiaremainedpositiveorrecrudescedafterdosing.Wedemonstratethatparasitesresistanttochloroquinehadcrossresistancetoamodiaquine,mefloquineandqinghaosuatvariousdegrees.Amodiaquine100mg/kg·d,mefloquine100mg/kg·dandqinghaosu200mg/kg·dexhibitednoobvioussuppressiveactivityonhighlypyronaridine-resistantlineofP.berghei,indicatingtheexistenceofcrossresistancetopyronaridine.更多還原【關鍵詞】伯氏瘧原蟲；咯萘啶；阿莫地喹；甲氟喹；青蒿素；抗藥性；交叉抗性；【Keywords】Plasmodiumberghei；pyionaridine；amodiaquine；mefloquine；q
【作者】葉秀玉；邵葆若；儲言紅；【Author】YeXiu-Yu,ShaoBao-Ruo,ChuYan-HongInstituteofParasiticDiseases,ChineseAcademyofPreventiveMedicine,Shanghai200025【機構】中國預防醫學科學院寄生蟲病研究所；中國預防醫學科學院寄生蟲病研究所上海200025；上海200025；上海200025；【摘要】用4天抑制試驗法給感染伯氏瘧原蟲ANKA株小鼠灌胃咯萘啶12.5mg/kg·d或阿莫地喹25mg/kg·d均能完全殺滅原蟲;甲氟喹25mg/kg·d或青蒿素100mg/kg·d雖有抑制作用但治愈率僅為50％及0％。
咯萘啶12.5mg/kg·d對中度抗氯喹的NS系原蟲亦有明顯作用,洽愈率70％,而阿莫地喹100mg/kg·d、甲氟喹100mg/kg·d及青蒿素200mg/kg·d均無治愈鼠,示后3種藥與氯喹有不同程度的交叉抗性。
上述劑量的阿莫地喹、甲氟喹和青蒿素對高度抗咯萘啶的伯氏瘧原蟲無明顯抑制作用,示它們與咯萘啶有交叉抗性。
更多還原【Abstract】TheasexualstagesofP.bergheiANKAwerecompletelyeliminatedasrevealedina"4-daysuppressivetest"withthedailydoseofpyronaridine12.5mgbase/kgoramodiaquine25mgbase/kg.Mefloquine25mgbase/kgandqinghaosu100mg/kgthoughexertedobvioussuppressiveeffect,thecurerateswereonly50%and0%,respectively.Intreatingchloroquine-sensitiveP.bergheiANKAstrainpyronaridineexhibitedthebesttherapeuticactivity,whichwasfollowedbyamodiaquine,mefloquineandqinghaosu.Intreatingmoderatelychloroquine-resistantP.bergheiNSlinethecurerateofpyronaridine12.5mg/kg·d×4was70%,butnoneofthe10infectedmicefromanygroupwascuredbyamodiaquine100mg/kg2d,mefloquine100mg/kg·dorqinghaosu200mg/kg·d.Thoughthelatter3drugsshowedprominentsuppressiveeffects,parasitemiaremainedpositiveorrecrudescedafterdosing.Wedemonstratethatparasitesresistanttochloroquinehadcrossresistancetoamodiaquine,mefloquineandqinghaosuatvariousdegrees.Amodiaquine100mg/kg·d,mefloquine100mg/kg·dandqinghaosu200mg/kg·dexhibitednoobvioussuppressiveactivityonhighlypyronaridine-resistantlineofP.berghei,indicatingtheexistenceofcrossresistancetopyronaridine.更多還原【關鍵詞】伯氏瘧原蟲；咯萘啶；阿莫地喹；甲氟喹；青蒿素；抗藥性；交叉抗性；【Keywords】Plasmodiumberghei；pyionaridine；amodiaquine；mefloquine；q