Structure, Cell Entry and Egress of Lassa Fever Virus. Lead Research Organisation: University of Oxford. Department Name: Structural Biology.FBB6E497-0DFD-470D-BF56-94DC9E8B68FDPhilippsUniversityofMarburgPhillipsUniverstaetMarburgBeigenstrasse10MarburgD-35032OutsideUKGermany31BAAEA1-1BCB-4D42-B1B3-4FC2539E6F43PublicHealthEnglandPortonDownSalisburyWiltshireSP40JGSouthWestUnitedKingdom3EAE04CA-9D62-4483-B9C4-F91AD9F4C5A9UniversityofOxfordStructuralBiologyUniversityChestWellingtonSquareOxfordOX12JDSouthEastUnitedKingdomRO3EAE04CA-9D62-4483-B9C4-F91AD9F4C5A9UniversityofOxfordUniversityChestWellingtonSquareOxfordOX12JDSouthEastUnitedKingdomLEAD_ROFBB6E497-0DFD-470D-BF56-94DC9E8B68FDPhilippsUniversityofMarburgPhillipsUniverstaetMarburgBeigenstrasse10MarburgD-35032OutsideUKGermanyCOLLABORATOR31BAAEA1-1BCB-4D42-B1B3-4FC2539E6F43PublicHealthEnglandPortonDownSalisburyWiltshireSP40JGSouthWestUnitedKingdomCOLLABORATOR5813E8E7-5DC9-41E5-9DCE-DE79D5204162JuhaHuiskonen0000-0002-0348-7323PRINCIPAL_INVESTIGATORF232A815-C2A7-4AED-B451-EC73B16035A4ThomasAlexanderBowdenCO_INVESTIGATOR52652956-D830-47CE-B96C-793B1E99CB07Structure,CellEntryandEgressofLassaFeverVirusClosedResearchGrantMR/J007897/1LassavirusisthecausativeagentofaseriousdiseasecalledLassafever,anacuteandhemorrhagicfeveraffectingupto500,000peopleandkillingthousandsofpeopleinWest-Africaeachyear.Itiscarriedbyratsscavengingaroundhomesinepidemicareas,andspreadstohumansoftenthroughcontaminatedfoodorinhaleddriedraturineorfeces.Duetoitshighmortality,andthefactthatitcanspreadthroughairasaerosols,itisalsoaseriousriskthatLassaviruscouldbeusedasabiologicalweapon.Despiteitshighmedicalrelevanceandpotentialbiologicalthreats,therearenoapprovedvaccinesorspecificanti-viraltherapiesagainstLassavirus.SeveralbasicquestionsaboutLassavirusbiologyremainunanswered.Thisislargelyduetothehighpathogenicityofthisvirus,necessitatingallhandlingtobecarriedoutinlaboratorieswithultra-highbiosafety,whicharenotwidelyavailable.Inthisproject,wearecollaboratingwi