In conclusion, NDM-1-resistant bacteria exhibit multidrug resistance and spread to a certain extent in the hospital via efficient plasmid ...ThisarticleispartoftheResearchTopicAntimicrobialResistanceAsaGlobalPublicHealthProblem:HowCanWeAddressIt?Viewall50ArticlesArticlesIlanaL.CamargoInstituteofPhysicsofSãoCarlos,UniversityofSaoPaulo,BrazilAndresF.Opazo-CapurroUniversityofConcepcion,ChileZhiRuanZhejiangUniversity,ChinaTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionMaterialsandMethodsResultsDiscussionConclusionDataAvailabilityStatementEthicsStatementAuthorContributionsFundingConflictofInterestSupplementaryMaterialFootnotesReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataORIGINALRESEARCHarticleFront.Microbiol.,30April2020|https://doi.org/10.3389/fmicb.2020.00700ResistanceofKlebsiellapneumoniaeStrainsCarryingblaNDM–1GeneandtheGeneticEnvironmentofblaNDM–1TianxinXiang1†,ChuanhuiChen2†,JiangxiongWen3,YangLiu1,QiZhang1,NaCheng3,XiaopingWu3andWeiZhang2*1DepartmentofHospitalInfectionControl,TheFirstAffiliatedHospitalofNanchangUniversity,Nanchang,China2DepartmentofRespiratoryandCriticalCare,TheFirstAffiliatedHospitalofNanchangUniversity,Nanchang,China3DepartmentofInfectiousDisease,TheFirstAffiliatedHospitalofNanchangUniversity,Nanchang,ChinaObjective:Regionaldisseminationisthemajorcauseofthewidespreadprevalenceofaplasmid-encodingNDM-1enzyme.Weinvestigatedthedrugresistance,jointefficiency,andgeneenvironmentofaKlebsiellapneumoniaestraincarryingblaNDM–1gene.MaterialsandMethods:Carbapenem-non-susceptiblestrainswereanalyzedusingtheVITEK2Compact.StrainscarryingblaNDM–1wereidentifiedusingpolymerasechainreactionandsequencing.Antimicrobialsusceptibilitytestingandplasmidconjugationexperimentswerethenconduc