NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListFrontCellInfectMicrobiolv.8;2018PMC5786545FrontCellInfectMicrobiol.2018;8:4.Publishedonline2018Jan22.doi: 10.3389/fcimb.2018.00004PMCID:PMC5786545PMID:29404282Colonization,Infection,andtheAccessoryGenomeofKlebsiellapneumoniaeRebekahM.MartinandMichaelA.Bachman*AuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerDepartmentofPathology,MichiganMedicine,UniversityofMichigan,AnnArbor,MI,UnitedStatesEditedby:KathrynElizabethHolt,UniversityofMelbourne,AustraliaReviewedby:HaijianZhou,NationalInstituteforCommunicableDiseaseControlandPrevention(ChinaCDC),China;Hong-YuOu,ShanghaiJiaoTongUniversity,China;SylvainBrisse,InstitutPasteur,France*Correspondence:MichaelA.Bachmanude.hcimu.dem@hcabekimReceived2017Sep30;Accepted2018Jan5.Copyright©2018MartinandBachman.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(CCBY).Theuse,distributionorreproductioninotherforumsispermitted,providedtheoriginalauthor(s)orlicensorarecreditedandthattheoriginalpublicationinthisjournaliscited,inaccordancewithacceptedacademicpractice.Nouse,distributionorreproductionispermittedwhichdoesnotcomplywiththeseterms.ThisarticlehasbeencitedbyotherarticlesinPMC.KlebsiellapneumoniaeisaGram-negativepathogenthathasalargeaccessorygenomeofplasmidsandchromosomalgeneloci.ThisaccessorygenomedividesK.pneumoniaestrainsintoopportunistic,hypervirulent,andmultidrug-resistantgroupsandseparatesK.pneumoniaefromtwocloselyrelatedspecies,KlebsiellavariicolaandKlebsiellaquasipneumoniae.SomestrainsofK.pneumoniaeactasopportunisticpathogens,infectingcriticallyillandimmunocompromisedpatients.TheseK.pneumoniaeareacommoncauseofhealth-careassociatedinfectionsincludingpneumonia,urinarytractinfections(UTIs),andbloodstreaminfections.K.variicolaandK.quasipneumoniaeareoftenclinicallyindistinguishablefromopportunisticK.pneumoniae.OtherstrainsofK