Introduction. Kleine–Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia and to various degrees, behavioral or cognitive ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListAnnIndianAcadNeurolv.13(4);Oct-Dec2010PMC3021925AnnIndianAcadNeurol.2010Oct-Dec;13(4):241–246.doi: 10.4103/0972-2327.74185PMCID:PMC3021925PMID:21264130Kleine–Levinsyndrome:Etiology,diagnosis,andtreatmentSantoshRamdurgSantoshRamdurgDepartmentofPsychiatry,AllIndiaInstituteofMedicalSciences,AnsariNagar,NewDelhi110029,IndiaFindarticlesbySantoshRamdurgAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerDepartmentofPsychiatry,AllIndiaInstituteofMedicalSciences,AnsariNagar,NewDelhi110029,IndiaForcorrespondence:Dr.SantoshRamdurg,DepartmentofPsychiatry,AllIndiaInstituteofMedicalSciences,AnsariNagar,NewDelhi110029,India.E-mail:moc.liamg@grudmarhsotnasReceived2010Jun27;Revised2010Jul25;Accepted2010Aug9.Copyright©AnnalsofIndianAcademyofNeurologyThisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.ThisarticlehasbeencitedbyotherarticlesinPMC.Kleine–Levinsyndrome(KLS)isararesleepdisordermainlyaffectingteenageboysinwhichthemainfeaturesareintermittenthypersomnolence,behavioralandcognitivedisturbances,hyperphagia,andinsomecaseshypersexuality.Eachepisodeisofbriefdurationvaryingfromaweekto1–2monthsandaffectedpeopleareentirelyasymptomaticbetweenepisodes.Nodefinitecausehasbeenidentified,andnoeffectivetreatmentsareavailableeventhoughillnessishavingwell-definedclinicalfeatures.Multiplerelapsesoccureveryfewweeksormonths,andtheconditionmaylastforadecadeormorebeforespontaneousresolution.Inthisstudy,PubMedwassearchedandappropriatearticleswerereviewedtohighlightetiology,clinicalfeatures,andmanagementofKLS.Onthebasisofthisknowledge,practicalinformationisofferedtohelpclinician