The Mechanisms of Catalysis by Metallo β-Lactamases | new delhi metallo-beta-lactamase
NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListBioinorgChemApplv.2008;2008PMC2422870BioinorgChemAppl.2008;2008:576297.Publishedonline2008Jun4.doi: 10.1155/2008/576297PMCID:PMC2422870PMID:18551183TheMechanismsofCatalysisbyMetalloβ-LactamasesMichaelI.Page*andAdrianaBadarauMichaelI.PageDepartmentofChemicalandBiologicalSciences,UniversityofHuddersfield,HuddersfieldHD13DH,UKFindarticlesbyMichaelI.PageAdrianaBadarauDepartmentofChemicalandBiologicalSciences,UniversityofHuddersfield,HuddersfieldHD13DH,UKFindarticlesbyAdrianaBadarauAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerDepartmentofChemicalandBiologicalSciences,UniversityofHuddersfield,HuddersfieldHD13DH,UK*MichaelI.Page:[email protected];Revised2008Jan29;Accepted2008Feb26.Copyright©2008M.I.PageandA.Badarau.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.ThisarticlehasbeencitedbyotherarticlesinPMC.ClassBβ-lactamasesormetallo-β-lactamases(MBLs)requirezincionstocatalysethehydrolysisofβ-lactamantibioticssuchaspenicillins,cephalosporins,carbapenems,andcephamycins.TherearenoclinicallyusefulinhibitorsagainstMBLswhichareresponsiblefortheresistanceofsomebacteriatoantibiotics.Therearetwometal-ionbindingsitesthathavedifferentzincligandsbuttheexactrolesofthemetal-ionremaincontroversial,anddistinguishingbetweentheirrelativeimportanceiscomplex.Themetal-ioncanactasaLewisacidbyco-ordinationtotheβ-lactamcarbonyloxygentofacilitatenucleophilicattackandstabilisethenegativechargedevelopedonthisoxygeninthetetrahedralintermediateanion.Themetal-ionalsolowersthepKaofthedirectlyco-ordinatedwatermoleculesothatthemetal-boundhydroxideionisabetternucleophilethanwaterandisusedtoattacktheβ-lactamcarbonylcarbon.Anintrinsicpropertyofbinuclearmet
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