New Delhi metallo-beta lactamase (NDM) produced by bacterial isolates from the Indian subcontinent are the latest carbapenemases, which ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFReviewOpenAccessPublished:27April2017Structure,GeneticsandWorldwideSpreadofNewDelhiMetallo-β-lactamase(NDM):athreattopublichealthAsadU.Khan1,LubnaMaryam1&RaffaeleZarrilli ORCID:orcid.org/0000-0003-4191-90322,3 BMCMicrobiologyvolume 17,Article number: 101(2017)Citethisarticle15kAccesses194Citations59AltmetricMetricsdetailsAbstractBackgroundTheemergenceofcarbapenemaseproducingbacteria,especiallyNewDelhimetallo-β-lactamase(NDM-1)anditsvariants,worldwide,hasraisedamajorpublichealthconcern.NDM-1hydrolyzesawiderangeofβ-lactamantibiotics,includingcarbapenems,whicharethelastresortofantibioticsforthetreatmentofinfectionscausedbyresistantstrainofbacteria.MainbodyInthisreview,wehavediscussedblaNDM-1variants,itsgeneticanalysisincludingtypeofspecificmutation,originofcountryandspreadamongseveraltypeofbacterialspecies.Widemembersofenterobacteriaceae,mostcommonlyEscherichiacoli,Klebsiellapneumoniae,Enterobactercloacae,andgram-negativenon-fermentersPseudomonasspp.andAcinetobacterbaumanniiwerefoundtocarrythesemarkers.Moreover,atleastseventeenvariantsofblaNDM-typegenedifferingintooneortworesiduesofaminoacidsatdistinctpositionshavebeenreportedsofaramongdifferentspeciesofbacteriafromdifferentcountries.Thegeneticandstructuralstudiesofthesevariantsareimportanttounderstandthemechanismofantibiotichydrolysisaswellastodesignnewmoleculeswithinhibitoryactivityagainstantibiotics.ConclusionThisreviewprovidesacomprehensiveviewofstructuraldifferencesamongNDM-1variants,whichareadrivingforcebehindtheirspreadacrosstheglobe.BackgroundAlthoughantibioticsweredevelopedtofightinfections,theemergenceofnewresistantmarkers,especiallyNewDelhi-metallo-beta-lactamases(NDM-1),hamperedthecapabilityofallantibioticsofbetalactamgrouptotreatinfectionscausedbymicroorganismscarryingsuchresistances.Thepossiblereasonfor