Dabie bandavirus | SFTSV

SFTSV is a tick-borne virus; it is not clear whether it can be transmitted by other blood-sucking arthropods. ... It can infect many mammalian hosts, including cats, ...DabiebandavirusFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchSpeciesofvirusDabiebandavirusVirusclassification(unranked):VirusRealm:RiboviriaKingdom:OrthornaviraePhylum:NegarnaviricotaClass:EllioviricetesOrder:BunyaviralesFamily:PhenuiviridaeGenus:BandavirusSpecies:DabiebandavirusSynonyms[1]SFTSvirusSFTSphlebovirusDabiemountainvirusSFTSbunyavirusHuaiyangshanbanyangvirusDabiebandavirus,alsocalledSFTSvirus,isatick-bornevirusinthegenusBandavirusinthefamilyPhenuiviridae,orderBunyavirales.[2]Theclinicalconditionitcausedisknownasseverefeverwiththrombocytopeniasyndrome(SFTS).[2]SFTSisanemerginginfectiousdiseasethatwasfirstdescribedinnortheastandcentralChina2009andnowhasalsobeendiscoveredinJapan,SouthKorea,VietnamandTaiwanin2015.SFTShasafatalityrateof12%andashighasover30%insomeareas.ThemajorclinicalsymptomsofSFTSarefever,vomiting,diarrhea,multipleorganfailure,thrombocytopenia(lowplateletcount),leukopenia(lowwhitebloodcellcount)andelevatedliverenzymelevels.AnotheroutbreakoccurredinEastChinaintheearlyhalfof2020.Contents1History2Genome3Evolution4Lifecycle5Epidemiology6ReferencesHistory[edit]In2009Xue-jieYuandcolleaguesisolatedtheSFTSvirus(SFTSV)fromSFTSpatients’blood.[2]Genome[edit]Thegenomehasbeensequenced.[2]Therearethreesegments—large(L),medium(M)andsmall(S).Fiveproteinshavebeenidentified—anRNAdependentRNApolymerase(RdRp),aglycoproteinN(Gn),aglycoproteinC(Gc),anuclearprotein(NP)andanonstructuralprotein(NSs).TheLsegmentencodestheRNApolymerasewith2084aminoacidresidues.TheMsegmentencodesoneopenreadingframeencoding1073aminoacidprecursorsofglycoproteins(GnandGc).TheSsegmenthas1746nucleotidesofambisenseRNAencodingtwoproteins,theNandNSsproteins.Theselieinoppositeorientationsandareseparatedbya54nucleotideintergenicregion.[3]Evolution[edit]Fivegenotypes(A–E)havebeenidentified.[4]StrainsfromChinacouldbeg


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