SFTSV has been suggested to be the causative pathogen of SFTS by recent studies [13]. SFTS is an insect or tick-borne contagious viral disease, ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFCaseReportOpenAccessPublished:05August2020MolecularidentificationofseverefeverwiththrombocytopeniasyndromevirusesfromtickandbittenpatientinSoutheastChinaYongxiTong1,QiujingWang ORCID:orcid.org/0000-0001-9693-45772,YongfengFu3,ShiboLi2,ZhaoZhang4,ZheenZhang2&XuewenYu2 VirologyJournalvolume 17,Article number: 122(2020)Citethisarticle1154Accesses3AltmetricMetricsdetailsAbstractBackgroundSeverefeverandthrombocytopeniabunyavirus(SFTSV)infectioncausesseverefeverandthrombocytopeniasyndromewithhighmortality.Itisextremelyrarethatatransmittingtickcanbedirectlycapturedinbitewounds,andthatSFTSVcanbeisolatedfromboththecapturedtickandpatient’sserumtoestablishasolidpathogendiagnosis.CasepresentationWereportacaseinfectedwithseverefeverandthrombocytopeniabunyavirus.The69-year-oldmalepatientpresentedwithfeverandtendernessontwolymphnodesintherightgroin.Avisibletickbitemarkappearedonrightupperquadrantofthepatient’sabdomen,andalivetickwascapturedinthebitewounduponphysicalexamination.Theviruswasdetectedinboththebloodofthepatientandinthetickthatstayedinthebitewoundfor7days.ThephylogeneticanalysisindicatedthattheSFTSVisolatedfromthetickandthepatient’sserumsamplebelongedtotypeB,inwhichtheL/Ssegmentofthesetwoisolatesshared100%homology,whiletheMsegmenthad99.9%homology.Thebittenpatientwasgivenvarioussupportivecare,buteventuallydiedofmultipleorganfailure.ConclusionThepresentcaseprovidesstrongevidenceofSFTSVtransmissionfromH.longicornistohumans,andsuggeststhatdirectcross-speciestransmissioncanoccurwithoutadditionalintermediatehosts.BackgroundSeverefeverwiththrombocytopeniasyndrome(SFTS)isaninfectiousdiseasethathasbeenreportedin20provincesinChina,includingHenan,Hubei,Shandong,Anhui,LiaoningandZhejiang[1].Recently,SFTShasalsobeenreportedinJapanandKorea[2,3].ThecausativeSFTSpathogenisseve