Whatpatientsandcaregiversneedtoknowabout cancer,coronavirus,andCOVID-19.CloseCriticalAlertBannerSearchVerenespañol|Downloadthistopic[PDF]TreatingNon-HodgkinLymphomaChemotherapyforNon-HodgkinLymphomaImmunotherapyforNon-HodgkinLymphomaTargetedDrugTherapyforNon-HodgkinLymphomaRadiationTherapyforNon-HodgkinLymphomaHigh-DoseChemotherapyandStemCellTransplantforNon-HodgkinLymphomaSurgeryforNon-HodgkinLymphomaPalliativeandSupportiveCareforNon-HodgkinLymphomaTreatingB-CellNon-HodgkinLymphomaTreatingT-CellNon-HodgkinLymphomaTreatingHIV-AssociatedLymphomaCancerA-ZNon-HodgkinLymphomaTreatingNon-HodgkinLymphomaTreatingB-CellNon-HodgkinLymphomaNon-Hodgkinlymphoma(NHL)isgenerallydividedinto2maintypes,basedonwhetheritstartsinBlymphocytes(Bcells)orTlymphocytes(Tcells).TherearemanydifferenttypesofB-celllymphomas.Treatmentusuallydependsbothonthetypeoflymphomaandthestage(extent)ofthedisease,butmanyotherfactorscanbeimportantaswell.DiffuselargeB-celllymphomaDiffuselargeB-celllymphoma(DLBCL)tendstogrowquickly.Mostoften,thetreatmentischemotherapy(chemo),usuallywitharegimenof4drugsknownasCHOP(cyclophosphamide,doxorubicin,vincristine,andprednisone),plusthemonoclonalantibodyrituximab(Rituxan).Thisregimen,knownasR-CHOP,ismostoftengivenincycles3weeksapart.Becausethisregimencontainsthedrugdoxorubicin,whichcandamagetheheart,itmaynotbesuitableforpatientswithheartproblems,sootherchemoregimensmaybeusedinstead.StageIorIIForDLBCLthatisonlyin1or2lymphnodegroupsonthesamesideofthediaphragm(thethinmusclethatseparatesthechestfromtheabdomen),R-CHOPisoftengivenfor3to6cycles,whichmightbefollowedbyradiationtherapytotheaffectedlymphnodeareas.StageIIIorIVMostdoctorswillgive6cyclesofR-CHOPasfirst-linetreatment.Afterseveralcycles,doctorsmaygetimagingtestssuchasaPET/CTscantoseehowwelltreatmentisworking.Peoplewhohaveahigherriskofthelymphomacomingbacklaterinthetissuesaroundthebrainandspinalcordmaybetreatedwithchemoinjectedintothespinalfluid(calledintrathecalchemotherapy).Anotheroptionistogivehighdosesofmethotrexatein