StagingNCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermDiffuseLargeBCellLymphomaSandeepA.Padala;AvyaktaKallam.AuthorInformationAuthorsSandeepA.Padala1;AvyaktaKallam2.Affiliations1AugustaUMC/MedicalCollegeofGeorgia2UniversityofNebraskaMedicalCenterLastUpdate:August2,2021.ContinuingEducationActivityDiffuselargeBcelllymphoma(DLBCL)isthemostcommonlymphoma,accountingforabout25%to30%ofallthenon-Hodgkinlymphomas.Ittypicallypresentsasarapidlygrowingmassorenlarginglymphnodesinanodalorextranodalsite.Thoughaggressive,theydorespondwelltosixcyclesofrituximabalongwithcyclophosphamide,doxorubicin,vincristine,andprednisone(R-CHOP).ThisactivityreviewstheevaluationandtreatmentofDLBCLandhighlightstheroleoftheinterprofessionalteaminevaluatingandtreatingpatientswiththiscondition.Objectives:DescribethepathophysiologyoftheBcelllymphomas.Reviewtheworkupofthepatientswithlymphoma.OutlinesthetreatmentofBcelllymphomas,asitdependsnotonlyontheirstagingbutalsoonthetypeofthedisease(indolentoraggressive)andthemolecularsubtype.SummarizetheroleoftheinterprofessionalteammembersinoptimizingcollaborationandcommunicationtoensurepatientswithDLBCLreceivehigh-qualitycare,whichwillleadtobetteroutcomes.Accessfreemultiplechoicequestionsonthistopic.IntroductionLymphomaisthemalignancyofthelymphocytesinthelymphoidsystem,andthey canarise fromBlymphocytesorTlymphocytesorthenaturalkiller(NK)cellsduringtheirdifferentstagesofmaturation.ItcanbeclassifiedintoHodgkinsandNon-Hodgkinslymphoma(NHL). NHLconstitutesabout80%ofalllymphomas.B-cellsareknowntohavefunctionaldiversityandpropertyto transformintomultiplepathways.[1] Due toitsfunctionaldiversity,itrepresentsaheterogeneousgroupofdiseasesvaryingclinicallyandpathologically. Morethan30subty