Background. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with the high case-fatality rate, and lack ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearcharticleOpenAccessPublished:05August2020Severefeverwiththrombocytopeniasyndrome:asystematicreviewandmeta-analysisofepidemiology,clinicalsigns,routinelaboratorydiagnosis,riskfactors,andoutcomesZhiquanHe1,BohaoWang1,YiLi2,3,YanhuaDu2,3,HongxiaMa2,3,XingleLi2,3,WanshenGuo2,BianliXu2&XueyongHuang2,3 BMCInfectiousDiseasesvolume 20,Article number: 575(2020)Citethisarticle1416Accesses2Citations1AltmetricMetricsdetailsAbstractBackgroundSeverefeverwiththrombocytopeniasyndrome(SFTS)isanemerginginfectiousdiseasewiththehighcase-fatalityrate,andlackofvaccines.Weaimedtosystematicallyanalysedtheepidemiologicalcharacteristics,clinicalsigns,routinelaboratorydiagnosis,riskfactors,andoutcomes.MethodsDocumentsonSFTSwerecollectedbysearchingtheChineseNationalKnowledgeInfrastructure,WanFangData,PubMed,Embase,andWebofSciencedatabasesfrom2011to2018.Meta-analysiswasperformedbyusingReviewManagerandStatasoftware.ResultsTwenty-fivearticlesinvolving4143caseswereincluded.Diarrhea(oddsratio(OR)=1.60,95%confidenceinterval(CI):1.06to2.42,P = 0.02),andvomiting(OR = 1.56,95%CI:1.01to2.39,P = 0.04)onadmissionwereassociatedwiththefataloutcomesofSFTS.Comparedtopatientswithmildsymptoms,patientswithseveresymptomshadsignificantlyelevatedlevelsoflacticaciddehydrogenase(standardmeandifference(SMD)=1.27,95%CI:0.59to1.94),alanineaminotransferase(SMD = 0.55,95%CI:0.24to0.85),aspirateaminotransferase(SMD = 1.01,95%CI:0.69to1.32),andcreatinekinase(SMD = 1.04,95%CI:0.74to1.33)buthadreducedplateletcounts(SMD = -0.87,95%CI:− 1.16to− 0.58)andalbuminlevels(SMD = -1.00,95%CI:− 1.32to− 0.68).Theriskfactorsforpoorprognosisincludedage(meandifference(MD)=6.88,95%CI:5.41to8.35)andfarming(OR = 2.01,95%CI:1.06to3.80).FortheriskfactorsofcontractingSFTS,theincidenceofSFTSrelatedtotickbiteswas24%[95%CI:0.18to0.31].Th