Ann Arbor Staging System · M+ = marrow · L+ = lung · H+ = liver · P+ = pleura · O+ = bone · D+ = skin and subcutaneous tissue.SurgicalPathologyCriteria–SearchThisSiteOnlyStanfordMedicalSitesWaystoGiveFindaPersonAlumniLaneLibraryWaystoGiveFindaPersonDiffuseLargeBCellLymphomaGrading/Staging/ReportDiffuselargeBcelllymphomasnotcurrentlygradedPreviously,theimmunoblasticvariantwasconsideredhighgradeSubsequentstudieshaveshownnodifferenceinprognosisAdverseprognosticfactorsreportedincludeHighprolferationratemeasuredbyKi67stainingbcl2expressionp53overexpressionAnnArborStagingSystemStageIIifinvolvementofasinglelymphnoderegionIEifinvolvementofasingleextralymphaticorganorsiteStageIIIIiftwoormorelymphnoderegionsonsamesideofdiaphragmIIEiflocalizedinvolvementofanextralymphaticorganorsiteandoneormorelymphnoderegionsonthesamesideofthediaphragmStageIIIIIIifInvolvementoflymphnoderegionsonbothsidesofthediphragmIIISifspleeninvolvedIIIEifextralymphaticsiteinvolvedStageIVDiffuseordisseminatedinvolvementofoneormoreextralymphaticorgansortissues,withorwithoutassociatedlymphnodeinvolvementSystemicSymptomsin6monthsprecedingadmissionFever,nightsweats,10%weightlossA=absentB=presentExtranodalsitesarealsodesignatedM+=marrowL+=lungH+=liverP+=pleuraO+=boneD+=skinandsubcutaneoustissueAlthoughoriginallydesignedforHodgkinlymphoma,theAnnArborSystemisalsousedfornon-Hodgkinlymphomas.Thepathologyreportshouldcontainthefollowinginformation:DiagnosisintheWorldHealthOrganization(WHO)classificationEquivalentdiagnosisinotherclassificationsusedbyrelevantcliniciansResultsofsupplementarystudiesifperformedRelationshiptootherspecimensfromthesamepatientInformationrelevanttostagingifavailableYouareHere:StanfordMedicine»SchoolofMedicine»Departments»SurgicalPathologyCriteria»DiffuseLargeBCellLymphomaNavigationforThisSection:SurgicalPathologyCriteriaDiagnosticCriteriaSupplementalStudiesDifferentialDiagnosisClinicalGrading/Staging/ReportClassification/ListsBibliographyPrintableVersionAdditionalLinks:GeneralLinksSurgicalPath