Diffuse large B cell lymphoma is the most common subtype of non-Hodgkin lymphoma. ... Staging. See the article on lymphoma staging.×ArticlesLogInCasesSignUpCoursesQuizDonateAbout×MenuSearchADVERTISEMENT:Radiopaediaisfreethankstooursupportersandadvertisers.BecomeaGoldSupporterandseenoads.ArticlesCasesCoursesLogInLoginSignup{"url":"/signup-modal-props.json?lang=us\u0026email="}ArticlesCasesCoursesQuizAboutRecentEditsGoad-freeSearchDiffuselargeBcelllymphomaLastrevisedbyDrYairGlick◉on15Oct2021EditarticleViewrevisionhistoryReportproblemwithArticleCitation,DOIandarticledataCitation:Deng,F.,Glick,Y.DiffuselargeBcelllymphoma.Referencearticle,Radiopaedia.org.(accessedon19Oct2021)https://doi.org/10.53347/rID-70781DOI:https://doi.org/10.53347/rID-70781Permalink:https://radiopaedia.org/articles/70781rID:70781Articlecreated:04Sep2019byDrFrancisDeng◉Revisions:3timesby3users-seefullrevisionhistorySystems:Oncology,HaematologySections:-Tags:cases,refsSynonyms:DiffuselargeB-celllymphoma,nototherwisespecifiedURLofArticleDiffuselargeBcelllymphoma isthemostcommonsubtypeofnon-Hodgkinlymphoma.EpidemiologyAssociationsDiffuselargeBcelllymphomaissometimesassociatedwithimmunodeficiency,includingacquiredimmunodeficiencysyndrome.PathologyClassificationIn2016WHOclassificationoflymphoidneoplasms,diffuselargeBcelllymphoma,nototherwisespecified(NOS),isatypeofmatureBcellneoplasmandincludestwomolecularsubgroupsindicatingcelloforigin:germinalcenterBcelltypeactivatedBcelltypeInaddition,diffuselargeBcelllymphomaswithcertainmolecular/cytogeneticfeaturespreviouslycalled"double-hit"or"triple-hit"lymphomasaswellasthoseresemblingBurkittlymphomaarenowclassifiedtogetheraseitherofthefollowingentities1:high-gradeB-celllymphomawithMYCandBCL2and/orBCL6rearrangements high-gradeB-celllymphoma,nototherwisespecifiedThereareotherwisemultiplespecifiedtypesofdiffuselargeBcelllymphoma:T-cell/histiocyte-richlargeBcelllymphomaprimarydiffuselargeBcelllymphomaofthecentralnervoussystemprimarycutaneousdiffuselargeBcelllymphoma,