韋尼克式氏腦病變(Wernicke encephalopathy)是一種缺乏thiamine(維生素B1) 的神經系統疾病，典型的症狀是眼肌麻痺(ophthalmoplegia)、共濟 ...急診小醫師https://dictionary.cambridge.org/zht/日誌相簿影音好友名片201001250817酒精對身體的不良反應alcoholethanolmetabolismkinetics?內科2016-07-06http://emedicine.medscape.com/article/794583-overvie來自EMNOTE~~ WernickeEncephalopathy(vitaminB1deficiency)ClassicTriad1.Ataxia2.Ophthalmoplegia(classicallynystagmusandlateralrectuspalsy)3.AlteredMentalStatusorconfusionTreatment:Thiamine500mgIVQ8X3days.Followwiththiamine250mgIVQ24X3-5days.在缺乏thiamine的狀態,給予病患糖分補充,可能造成血液循環中的thiamine不足,引起神經損傷.(加重Wernicke'sencephalopathy.)Inaddition,theadministrationofdextroseinthesettingofthiaminedeficiencycanbeharmfulbecauseglucoseoxidationisathiamine-intensiveprocessthatmaydrivetheinsufficientcirculatingvitaminB-1intracellularly,therebyprecipitatingneurologicinjury.(SeeEtiology.)[2]http://er119org.blogspot.tw/2012/07/wernickes-encephalopathy.htmlWernicke’sEncephalopathyClinicalPearls:Wernicke’sEncephalopathyWhatarethetypicalmanifestationsofWernicke’sencephalopathy?Wernicke’sencephalopathy,whichiscausedbyadeficiencyofthiamine(vitaminB1),isdescribedasanencephaloneuropathicsyndromeconsistingofchangesinmentalstatus(confusion,confabulation,short-termmemoryloss,andpsychosis),oculardysfunction(nystagmus,gazepalsies,andophthalmoplegia),andgaitataxia.Usuallybeginningwithdoublevision,dysarthria,ataxia,andparesthesiasofthelegs,Wernicke’sencephalopathycanrapidlyprogresstoKorsakoff’ssyndrome,whichischaracterizedbyanterogradeandretrogradeamnesia,confabulation,meagercontentinconversation,lackofinsight,andapathy.Howshouldthiaminedeficiencybetreated?Clinicallysignificantthiaminedeficiencyistypicallytreatedwithatleast200mgofparenteralthiaminedailyfor2days,withsomeexpertsrecommending500mgthreetimesdailyfor2days,followedby500mgoncedailyfor5days.Oncompletionofparenteraltreatment,thepatientshouldtakeanoralthiaminesupplementdaily.GivingpatientswiththiaminedeficiencyglucosebeforeadministeringthiaminecanprecipitateorworsenWernicke’sencephalopathy.T